Dose-related effect of methylphenidate on stopping and changing in children with attention-deficit/hyperactivity disorder
Dose-related effect of methylphenidate on stopping and changing in children with attention-deficit/hyperactivity disorder
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DOI：
10.1016/j.eurpsy.2005.04.003
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发表时间：
2006-12-01
影响因子：
7.8
通讯作者：
van Engeland, Herman
中科院分区：
文献类型：
--
作者：
Lijffijt, Marijn;Kenemans, J. Leon;van Engeland, Herman
目的。 - 哌醋甲酯 (MPH) 对注意力缺陷/多动障碍 (ADHD) 儿童通过停止任务评估的抑制控制的影响可能受到任务难度的影响，并且可能由注意力介导。主题和方法。 - 15 名 ADHD 儿童在受试者内设计中使用安慰剂、0.5 和 1.0 mg/kg MPH 后执行停止和改变任务。结果。 - 线性趋势分析显示 MPH 在这两项任务中具有类似的效果，并且对抑制控制的效果比对注意力的效果更强。此外，还发现去甲肾上腺素和多巴胺的血清代谢物分别用于注意力措施和抑制控制措施之间存在相关性。讨论和结论。 - 在患有 ADHD 的儿童中，MPH 主要作用于抑制控制，并且不受任务难度的影响。此外，注意力和抑制控制可能具有不同的药理学特征。 (c) 2005 年 Elsevier Masson SAS。版权所有。
Purpose. - The effect of methylphenidate (MPH) on inhibitory control as assessed by the stop task in children with attention-deficit/hyperactivity disorder (ADHD) could be influenced by task difficulty and may be mediated by attention.Subjects and methods. - Fifteen children with ADHD performed the stop and the change task after placebo, 0.5 and 1.0 mg/kg MPH in a within-subject design.Results. - Linear-trend analysis showed a similar effect of MPH in both tasks and a stronger effect for inhibitory control than for attention. Furthermore, a correlation was found between blood serum metabolites of norepinephrine and dopamine for attentional measures and inhibitory control measures, respectively.Discussion and conclusion. - In children with ADHD MPH could act primarily on inhibitory control, and is not influenced by task difficulty. Also, attention and inhibitory control could have differential pharmacological profiles. (c) 2005 Elsevier Masson SAS. All rights reserved.