Planar Organization of Multiciliated Ependymal (E1) Cells in the Brain Ventricular Epithelium.
Planar Organization of Multiciliated Ependymal (E1) Cells in the Brain Ventricular Epithelium.
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DOI：
10.1016/j.tins.2016.05.004
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发表时间：
2016-08
影响因子：
15.9
通讯作者：
Alvarez-Buylla A
中科院分区：
文献类型：
--
作者：
Ohata S;Alvarez-Buylla A
脑脊液（CSF）持续流经脑室，这是大脑稳态必不可少的过程。多纤毛室管膜（E1）细胞排列在心室壁，并通过纤毛搏动对CSF流动做出重要贡献。这一功能的关键是E1细胞的旋转和平移平面细胞极性（PCP）。E1细胞PCP的缺陷可导致异常CSF积聚和脑积水。在这里，我们整合了最新的数据，早期CSF流在胚胎脑室，PCP调节器（如Vangl2和Dishevelled）的作用，和细胞骨架网络的建立，完善和维护E1细胞的PCP。E1细胞的平面组织机制可以解释CSF流动如何有助于脑功能，并可能有助于脑积水的诊断和预防。
Cerebrospinal fluid (CSF) continuously flows through the cerebral ventricles, a process essential for brain homeostasis. Multiciliated ependymal (E1) cells line the walls of the ventricles and contribute importantly to CSF flow through ciliary beating. Key to this function is E1 cells’ rotational and translational planar cell polarity (PCP). Defects in E1 cells’ PCP can result in abnormal CSF accumulation and hydrocephalus. Here we integrate recent data on the roles of early CSF flow in the embryonic ventricles, PCP regulators (e.g. Vangl2 and Dishevelled), and cytoskeletal networks in the establishment, refinement, and maintenance of E1 cells’ PCP. E1 cells’ planar organization mechanisms could explain how CSF flow contributes to brain function and may help in the diagnosis and prevention of hydrocephalus.