Sonic Estimation of Elasticity via Resonance: A New Method of Assessing Hemostasis.
Sonic Estimation of Elasticity via Resonance: A New Method of Assessing Hemostasis.
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DOI：
10.1007/s10439-015-1460-y
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发表时间：
2016-05
影响因子：
3.8
通讯作者：
Walker WF
中科院分区：
文献类型：
--
作者：
Corey FS;Walker WF
不受控制的出血威胁着接受大手术和治疗创伤性损伤的患者。本文介绍了一种诊断凝血功能障碍的新方法，通过重复测量血液样本的剪切模量，因为它在体外凝结。每次测量应用高能量超声脉冲以在刚性壁室内感生剪切波，然后使用低能量超声脉冲来测量与该剪切波的共振相关联的位移。测量的位移与时域有限差分（FDTD）模型的预测相关，最佳拟合对应于模量估计。在我们目前的实现中，每次测量需要62.4 ms。实验数据进行了分析，使用固定粘度算法和自由粘度算法。在利用暴露于高岭土诱导人血凝块的实验中，自由粘度算法定量了形成凝块的剪切模量，最差情况精密度为2.5%。采用固定粘度算法，精度提高到1.8%。重复测量表明，从液态血液平稳演变为剪切模量在1.4 kPa和3.3 kPa之间的坚固凝块。这些结果显示了该技术用于凝血的快速护理点评估的前景。
Uncontrolled bleeding threatens patients undergoing major surgery and in care for traumatic injury. This paper describes a novel method of diagnosing coagulation dysfunction by repeatedly measuring the shear modulus of a blood sample as it clots in vitro. Each measurement applies a high-energy ultrasound pulse to induce a shear wave within a rigid walled chamber, and then uses low energy ultrasound pulses to measure displacements associated with the resonance of that shear wave. Measured displacements are correlated with predictions from Finite Difference Time Domain (FDTD) models, with the best fit corresponding to the modulus estimate. In our current implementation each measurement requires 62.4 ms. Experimental data was analyzed using a fixed-viscosity algorithm and a free-viscosity algorithm. In experiments utilizing human blood induced to clot by exposure to kaolin, the free-viscosity algorithm quantified the shear modulus of formed clots with a worst-case precision of 2.5%. Precision was improved to 1.8% by utilizing the fixed-viscosity algorithm. Repeated measurements showed a smooth evolution from liquid blood to a firm clot with a shear modulus between 1.4 kPa and 3.3 kPa. These results show the promise of this technique for rapid, point of care assessment of coagulation.
影响因子：
2.9
作者：
Mauldin, F. William, Jr.;Viola, Francesco;Walker, William F.
通讯作者：
Walker, William F.