Abnormal β-catenin immunohistochemical expression as a prognostic factor in gastric cancer: A meta-analysis
Abnormal β-catenin immunohistochemical expression as a prognostic factor in gastric cancer: A meta-analysis
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DOI：
10.3748/wjg.v20.i34.12313
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发表时间：
2014-09-14
影响因子：
4.3
通讯作者：
Jiang, Bo
中科院分区：
文献类型：
--
作者：
Li, Li-Fu;Wei, Zheng-Jie;Jiang, Bo
目的：目的：探讨β-连环蛋白（beta-catenin，β-catenin）免疫组化表达对胃癌（gastric cancer，GC）预后的影响。检索于2013年11月10日结束，无日期下限。与研究相关的引文列表用于识别其他合格的研究。我们纳入的研究报告了足够的信息来估计HR和95%CI，以及在临床病理学特征分析中估计OR的信息。使用Newcastle-Ottawa质量评估量表评估这些研究的质量。使用Review Manager 5.2计算HR和OR及其方差。结果：共检索到24篇文献，包含3404例病例。β-连环蛋白表达与胃癌患者的总生存率（OS）显著相关（HR = 1.85，95%CI：1.39-2.46），但表现出显著的异质性（I-2 = 71%，P < 0.0001）。亚组分析表明，β-连环蛋白表达的异常模式对OS有不利影响（HR = 1.79，95%CI：1.39-2.32）。然而，在细胞核中的积累或膜的损失并不影响GC患者的生存独立。此外，β-连环蛋白的联合OR表明β-连环蛋白表达与Lauren分类相关，（OR = 1.98，95%CI：1.19-3.29），淋巴结转移（OR = 2.00，95%CI：1.44-2.77）、远处转移（OR = 2.69，95%CI：1.35-5.38）和分化程度（OR = 2.68，95%CI：1.66-4.34）。β-catenin表达与TNM分期无关（OR = 1.3495%CI：0.96-1.86），浸润深度（OR = 1.48，95%CI：0.94-2.33）或血管浸润（OR = 1.11，95%CI：0.70-1.76）。β-catenin的异常表达可能与胃癌的进展有关，并可能是胃癌患者预后不良的预测因素。(C)2014百世登出版集团股份有限公司All rights reserved.
AIM: To evaluate the effect of beta-catenin immunohistochemical expression on the prognosis of gastric cancer (GC).METHODS: We searched Pubmed and Embase to identify eligible studies. The search ended on November 10, 2013, with no lower date limit. The citation lists associated with the studies were used to identify additional eligible studies. We included studies reporting sufficient information to estimate the HR and 95%CI, and information to estimate the OR in the analysis of clinicopathological features. The qualities of these studies were assessed using the Newcastle-Ottawa Quality Assessment Scale. HRs and ORs and their variance were calculated and pooled using Review Manager Version 5.2.RESULTS: A total of 24 studies were identified and comprised 3404 cases. beta-catenin expression was significantly correlated with poor overall survival (OS) in GC patients (HR = 1.85, 95%CI: 1.39-2.46), but showed a significant degree of heterogeneity (I-2 = 71%, P < 0.0001). Subgroup analysis indicated that an abnormal pattern of beta-catenin expression had an unfavorable effect on OS (HR = 1.79, 95%CI: 1.39-2.32). However, accumulation in the nucleus or loss of membrane did not influence the survival of GC patients independently. Moreover, the combined OR of beta-catenin indicated that beta-catenin expression was associated with Lauren classification (OR = 1.98, 95%CI: 1.19-3.29), lymph node metastasis (OR = 2.00, 95%CI: 1.44-2.77), distant metastasis (OR = 2.69, 95%CI: 1.35-5.38) and grade of differentiation (OR = 2.68, 95%CI: 1.66-4.34). beta-catenin expression did not correlate with TNM stage (OR = 1.34 95%CI: 0.96-1.86), the depth of invasion (OR = 1.48, 95%CI: 0.94-2.33) or vascular invasion (OR = 1.11, 95%CI: 0.70-1.76).CONCLUSION: Abnormal beta-catenin immunohistochemical expression may be associated with tumor progression and could be a predictive factor of poor prognosis in patients with GC. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.