Serotonin by stress interaction: a susceptibility factor for the development of depression?
Serotonin by stress interaction: a susceptibility factor for the development of depression?
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DOI：
10.1177/0269881106075588
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发表时间：
2007-07-01
影响因子：
4.1
通讯作者：
Markus, C. Rob
中科院分区：
文献类型：
--
作者：
Firk, Christine;Markus, C. Rob
抑郁症的遗传易感性可能是抑郁症发展的潜在危险因素。虽然这种倾向的神经生物学等价物尚不清楚，但似乎大脑5-羟色胺（5-HT）系统起着重要的中介作用。因此，有抑郁症家族史（FH+）的个体可能更容易因与大脑中的多巴胺能神经传递改变相关的先天脆弱性而患上抑郁症。然而，一个主要的问题是，大脑5-HT在抑郁症中的作用是复杂的，这种与降钙素相关的先天脆弱性本身不足以引起抑郁发作。在寻找其他因素的过程中，压力受到了特别的关注。压力性生活事件影响并先于抑郁症的发作。此外，抑郁症与应激激素失调有关，并且认为神经内分泌应激系统和5-HT系统中的应激相关变化之间发生双向相互作用。在目前的审查中，我们认为，健康的人与抑郁症的积极的家族史更容易发展抑郁症，由于遗传5-HT的易感性，恶化的压力应对机制，增加压力的脆弱性。
A genetic predisposition to depression may be a potential risk factor in the development of depression. Although the neurobiological equivalent of the predisposition remains unclear, it seems as though the brain serotonin (5-HT) system plays an important mediating role. Therefore, individuals with a family history of depression (FH+) may be more Likely to develop depression due to an innate vulnerability related to altered serotonergic neurotransmission in the brain. A major problem, however, is that the role of brain 5-HT in depression is complex and this serotonin-related innate vulnerability, by itself, is not sufficient enough to cause a depressive episode. In the search for additional factors, stress has received particular attention. Stressful life events influence and precede the onset of depression. Furthermore, depression is associated with stress hormone dysregutation and bidirectional interactions are thought to occur between stress-retated changes in the neuroendocrine stress system and the 5-HT system. In the current review, we argue that healthy individuals with a positive family history of depression are more prone to develop depression due to a genetic 5-HT susceptibility, which deteriorates stress coping mechanisms and increases stress vulnerability.