Overexpression of MUC1 predicts poor prognosis in patients with breast cancer.
Overexpression of MUC1 predicts poor prognosis in patients with breast cancer.
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DOI：
10.3892/or.2018.6887
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发表时间：
2019-03
期刊：
影响因子：
4.2
通讯作者：
Cui X
中科院分区：
文献类型：
--
作者：
Jing X;Liang H;Hao C;Yang X;Cui X
乳腺癌是女性中最常见的癌症；因此，迫切需要确定精确的生物标志物来诊断和治疗该疾病。Mucin 1 （MUC1）是一种糖蛋白，已被证明参与多种肿瘤类型的转移和侵袭。通过生物信息学分析，提示MUC1在乳腺癌中的预后价值。此外，使用Oncomine分析评估MUC1的表达水平。此外，使用PrognoScan分析MUC1在乳腺癌中的预后价值。MUC1的突变通过Cancer体细胞突变目录和cBioPortal数据库进行分析。此外，加州大学圣克鲁兹分校（University of California, Santa Cruz， UCSC）检测了MUC1的甲基化状态。使用cbiopportal、UCSC和Breast Cancer Gene-Expression Miner v4.0数据集检测MUC1 mRNA的共表达。结果表明，MCU1在乳腺癌中经常过表达，并且与CpG位点呈负相关。此外，综合数据表明MUC1异常高表达预示预后不良。此外，MUC1表达上调与雌激素受体和孕激素受体阳性疾病、衰老以及Scarff、Bloom和Richardson分级升高有关，但与三阴性和基底样状态无关。随后在多个大型数据库中进行的数据挖掘表明，乳腺癌组织中MUC1 mRNA表达与环amp响应元件结合蛋白3-样4 （CREB3L4）呈正相关。目前的数据表明，MUC1的过表达预示着乳腺癌患者预后不良，并且与MUC1启动子甲基化状态有关。此外，MUC1与CREB3L4呈正相关，可能是乳腺癌的潜在预后因素和治疗靶点。
Breast cancer is the most commonly diagnosed cancer in females; thus, there is an urgent requirement to identify precise biomarkers for the diagnosis and treatment of the disease. Mucin 1 (MUC1) is a glycoprotein that has been demonstrated to be involved in the metastasis and invasion of multiple tumor types. Bioinformatics analyses were conducted to indicate the prognostic value of MUC1 in breast cancer. Additionally, the expression level of MUC1 was assessed using Oncomine analysis. Furthermore, PrognoScan was used to analyze the prognostic value of MUC1 in breast cancer. Mutations of MUC1 were analyzed by the Catalogue of Somatic Mutations in Cancer and cBioPortal databases. In addition, University of California, Santa Cruz (UCSC) was used to examine the methylation status of MUC1. Co-expression of MUC1 mRNA was detected with the cBioPortal, UCSC and Breast Cancer Gene-Expression Miner v4.0 datasets. The results demonstrated that MCU1 is frequently overexpressed in breast cancer and is negatively associated with CpG sites. Furthermore, pooled data indicated that abnormally high expression of MUC1 indicates poor prognosis. Additionally, upregulation of MUC1 expression is associated with estrogen receptor- and progesterone receptor-positive disease, aging and increased Scarff, Bloom and Richardson grade, but is not associated with triple-negative and basal-like status. Subsequent data mining across multiple large databases demonstrated a positive association between MUC1 mRNA expression and cyclic AMP-responsive element-binding protein 3-like 4 (CREB3L4) in breast cancer tissues. The present data indicated that the overexpression of MUC1 indicates a poor prognosis in patients with breast cancer and is associated with MUC1 promoter methylation status. Additionally, MUC1 positively correlated with CREB3L4 and may serve as a potential prognostic factor and therapy target for breast cancer.