Abnormal cortical thickness and brain-behavior correlation patterns in individuals with heavy prenatal alcohol exposure.
Abnormal cortical thickness and brain-behavior correlation patterns in individuals with heavy prenatal alcohol exposure.
复制标题
产前大量饮酒的个体皮质厚度异常和大脑行为相关模式。
DOI：
10.1093/cercor/bhm039
复制
发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Toga,ArthurW
中科院分区：
文献类型：
--
作者：
Sowell,ElizabethR;Mattson,SarahN;Kan,Eric;Thompson,PaulM;Riley,EdwardP;Toga,ArthurW
胎儿酒精谱系障碍（FASDs）儿童的定量磁共振成像（MRI）研究显示了畸形的区域模式，最突出的是顶叶和后颞皮质。在这些研究中使用了各种图像分析方法，但皮质厚度的异常尚未映射到FASD个体的整个皮质表面。此外，认知功能障碍和皮质厚度测量之间的关系尚未被探索。我们将皮质模式匹配算法和以毫米为单位测量皮质厚度的技术应用于21名重度产前酒精暴露的受试者（8-22岁，平均年龄12.6岁）和21名正常发育的对照受试者（8-25岁，平均年龄13.5岁）的脑MRI结构图像。言语回忆和视觉空间功能的可分离认知测量与皮层厚度相关，并且通过测试分数相互作用来评估预测皮层厚度的组。在FASD受试者的双侧颞叶、双侧下顶叶和右额叶区域，可观察到大面积的皮质厚度过剩，最高可达1.2 mm。在言语记忆和视觉空间记忆中，分别在右背额区和左枕区发现显著组间的相互作用。这些结果与我们自己和其他研究小组的早期分析一致，但我们首次表明，在产前酒精暴露的儿童中，右侧额叶区域的皮质厚度也增加了。此外，重要的相互作用首次表明，大脑-行为关系作为产前大量酒精暴露的功能而改变。
Quantitative magnetic resonance imaging (MRI) studies in children with fetal alcohol spectrum disorders (FASDs) have shown regional patterns of dysmorphology, most prominent in parietal and posterior temporal cortices. Various methods of image analysis have been employed in these studies, but abnormalities in cortical thickness have not yet been mapped over the entire cortical surface in individuals with FASD. Further, relationships between cognitive dysfunction and cortical thickness measures have not yet been explored. We applied cortical pattern matching algorithms and techniques for measuring cortical thickness in millimeters to the structural brain MRI images of 21 subjects with heavy prenatal alcohol exposure (8–22 years, mean age 12.6 years), and 21 normally developing control subjects (8–25 years, mean age 13.5 years). Dissociable cognitive measures, of verbal recall and visuospatial functioning, were correlated with cortical thickness, and group by test score interactions were evaluated for predicting cortical thickness. Significant cortical thickness excesses of up to 1.2 mm were observed in the FASD subjects in large areas of bilateral temporal, bilateral inferior parietal, and right frontal regions. Significant group by test score interactions were found in right dorsal frontal regions for the verbal recall measure and in left occipital regions for the visuospatial measure. These results are consistent with earlier analyses from our own and other research groups, but for the first time, we show that cortical thickness is also increased in right lateral frontal regions in children with prenatal alcohol exposure. Further, the significant interactions show for the first time that brain–behavior relationships are altered as a function of heavy prenatal alcohol exposure.