Structural and functional connectivity in healthy aging: Associations for cognition and motor behavior
Structural and functional connectivity in healthy aging: Associations for cognition and motor behavior
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DOI：
10.1002/hbm.23067
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发表时间：
2016-03-01
影响因子：
4.8
通讯作者：
Jaencke, Lutz
中科院分区：
文献类型：
--
作者：
Hirsiger, Sarah;Koppelmans, Vincent;Jaencke, Lutz
脑卒中相关的行为下降可能是白色物质束恶化的结果，影响静息状态下的脑结构（SC）和功能连接（FC）。到目前为止，尚不清楚SC和FC数据的组合是否可以比单独测量更好地预测认知/运动表现。我们在扣带束中探索了这些关系，扣带束是默认模式网络的主要白色物质通路。我们的目的是获得更深入的了解：（a）年龄和扣带的SC和FC强度之间的关系，（B）SC和FC之间的关联，特别是（c）扣带的SC和FC是如何与认知/运动性能单独和组合。我们在一个健康和受过良好教育的165名老年参与者（年龄在64-85岁）的样本中研究了这些关联。使用概率纤维束成像获取SC和FC，以分别获得捕获扣带束内白色物质完整性的措施（分数各向异性、平均、轴向和径向扩散率）和基于种子的静息状态功能性MRI相关方法。参与者进行了认知测试，测量处理速度，记忆和执行功能，以及运动测试，测量运动速度和握力。我们的数据显示，只有SC而不是静息状态FC与年龄显著相关。扣带回的SC与FC无相关性。认知/运动性能和SC/FC之间的不同关系被发现，但扣带回的SC和FC预测认知/运动性能的组合分析的加性效应是不明显的。《脑地图》37：855-867，2016年。(c)2015 Wiley Periodicals，Inc.
Age-related behavioral declines may be the result of deterioration of white matter tracts, affecting brain structural (SC) and functional connectivity (FC) during resting state. To date, it is not clear if the combination of SC and FC data could better predict cognitive/motor performance than each measure separately. We probed these relationships in the cingulum bundle, a major white matter pathway of the default mode network. We aimed to attain deeper knowledge about: (a) the relationship between age and the cingulum's SC and FC strength, (b) the association between SC and FC, and particularly (c) how the cingulum's SC and FC are related to cognitive/motor performance separately and combined. We examined these associations in a healthy and well-educated sample of 165 older participants (aged 64-85). SC and FC were acquired using probabilistic tractography to derive measures to capture white matter integrity within the cingulum bundle (fractional anisotropy, mean, axial and radial diffusivity) and a seed-based resting-state functional MRI correlation approach, respectively. Participants performed cognitive tests measuring processing speed, memory and executive functions, and motor tests measuring motor speed and grip force. Our data revealed that only SC but not resting state FC was significantly associated with age. Further, the cingulum's SC and FC showed no relation. Different relationships between cognitive/motor performance and SC/FC separately were found, but no additive effect of the combined analysis of cingulum's SC and FC for predicting cognitive/motor performance was apparent. Hum Brain Mapp 37:855-867, 2016. (c) 2015 Wiley Periodicals, Inc.