Prevention of neutrophil apoptosis by monosodium urate crystals
Prevention of neutrophil apoptosis by monosodium urate crystals
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DOI：
10.1007/bf01375654
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发表时间：
1997-03-01
影响因子：
4
通讯作者：
Kondo, H
中科院分区：
文献类型：
--
作者：
Akahoshi, T;Nagaoka, T;Kondo, H
研究了尿酸钠（MSU）晶体对培养的外周血中性粒细胞凋亡的影响。低浓度的 MSU 晶体以剂量和时间依赖性方式降低中性粒细胞自发凋亡率。 MSU晶体刺激的中性粒细胞的培养上清液也促进中性粒细胞凋亡的延迟。较高浓度的 MSU 晶体会迅速引起细胞裂解。这些发现表明，MSU 晶体能够通过在较低浓度下降低中性粒细胞凋亡率并在较高浓度下诱导细胞裂解来放大痛风性关节炎的炎症反应。
The effects of monosodium urate (MSU) crystals on apoptosis of cultured peripheral blood neutrophils were investigated. MSU crystals at low concentrations decreased the rate of spontaneous apoptosis of neutrophils in a dose- and time-dependent manner. The culture supernatant of MSU crystal stimulated neutrophils also promoted a delay in neutrophil apoptosis. MSU crystals at higher concentrations rapidly caused cell lysis. These findings indicated that MSU crystals are capable of amplifying the inflammatory responses of gouty arthritis by decreasing the rates of neutrophil apoptosis at lower concentrations and inducing cell lysis at higher concentrations.