Direct targets of phosphoinositide 3-kinase products in membrane traffic and signal transduction
Direct targets of phosphoinositide 3-kinase products in membrane traffic and signal transduction
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DOI：
10.1016/s0962-8924(98)01366-x
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发表时间：
1998-11-01
影响因子：
19
通讯作者：
Czech, MP
中科院分区：
文献类型：
--
作者：
Corvera, S;Czech, MP
磷酸肌醇3-激酶是一个脂质激酶家族，磷酸化磷脂酰肌醇和高磷酸化的多磷酸肌醇上肌醇环的3'位置。受这些酶活性影响的细胞功能的多样性引起了细胞生物学两个重要领域——信号转导和膜交通的研究人员的注意。本文讨论了最近发现的与3'-多磷酸肌苷直接相互作用的蛋白质是如何揭示这些基本细胞过程之间新的潜在联系的。
Phosphoinositide 3-kinases are a family of lipid kinases that phosphorylate the 3' position of the inositol ring on phosphatidylinositol and higher-phosphorylated polyphosphoinositides. The multiplicity of cellular functions influenced by the activity of these enzymes has captured the attention of researchers working on two important fields of cell biology - signal transduction and membrane traffic This review discusses how the recent identification of proteins that interact directly with 3'-polyphosphoinositides was revealed novel potential interconnections between these fundamental cellular processes.