Facile Fabrication of Silicon(IV)Phthalocyanine-Embedded Poly(vinyl alcohol)-Based Antibacterial and Antifouling Interfaces.
Facile Fabrication of Silicon(IV)Phthalocyanine-Embedded Poly(vinyl alcohol)-Based Antibacterial and Antifouling Interfaces.
复制标题
DOI：
10.1021/acsabm.0c00347
复制
发表时间：
2020-05
影响因子：
4.7
通讯作者：
Konstantin Strokov;A. Schäfer;U. Dobrindt;A. Galstyan
中科院分区：
文献类型：
--
作者：
Konstantin Strokov;A. Schäfer;U. Dobrindt;A. Galstyan
在细菌的光动力灭活作为抗生素治疗的替代方法的兴趣继续增长。基于这种方法，可以通过将光敏剂掺入聚合物基材料中来制备光激活抗感染界面。为了将联合收割机的光杀菌和杀菌功能结合起来，载体聚合物的选择具有特别重要的意义：它应该能够快速有效地缀合光敏剂并减少生物环境中人造材料上生物负载的形成。本研究报告一锅法制造和表征两个硅（IV）酞菁/聚（乙烯醇）为基础的静电纺丝毡。该方法依赖于使用癸二酸作为交联剂通过酯化使组分热交联。制造的柔性垫显示出对不同革兰氏阳性细菌的光敏剂依赖性抗菌光活性，对人成纤维细胞具有低细胞毒性作用，并且有效对抗细菌附着，作为未来生物膜形成的早期步骤。这项工作为开发可用于非粘性伤口敷料、食品包装、水和空气过滤的光敏材料和界面提供了实用指南。
Interest in the photodynamic inactivation of bacteria as an alternative method to antibiotic treatment continues to grow. Based on this approach, light-activated anti-infective interfaces could be fabricated via incorporation of photosensitizers into the polymer-based materials. In order to combine photobactericidal and antifouling functions, the choice of the carrier polymer is of particular significance: it should enable fast and effective conjugation of photosensitizer and reduce the formation of bioburden on the artificial material in a biological environment. This study reports one-pot fabrication and characterization of two silicon(IV)phthalocyanine /poly(vinyl alcohol)-based electrospun mats. The method relies on the thermal cross-linking of components by esterification using sebacic acid as a cross-linking agent. Fabricated flexible mats showed photosensitizer-dependent antibacterial photoactivity against different Gram-positive bacteria with low cytotoxic effects on human fibroblasts and were effective against bacterial attachment, as an early step toward future biofilm formation. This work provides practical guidelines in developing photoactive materials and interfaces that can be used in nonadhesive wound dressings, food packaging, water, and air filtration.