Similar effects of ethanol and flumazenil on acquisition of a shuttle-box avoidance response during withdrawal from chronic ethanol treatment.
Similar effects of ethanol and flumazenil on acquisition of a shuttle-box avoidance response during withdrawal from chronic ethanol treatment.
复制标题
乙醇和氟马西尼对退出长期乙醇治疗期间获得穿梭盒回避反应的类似作用。
DOI：
10.1111/j.1476-5381.1993.tb13876.x
复制
发表时间：
1993
影响因子：
7.3
通讯作者：
Breese,GR
中科院分区：
文献类型：
--
作者：
Criswell,HE;Breese,GR
1.乙醇促进了双向梭箱回避反应的获得。这有利于收购的回避反应，乙醇在退出慢性乙醇饮食摄入量（即乙醇的耐受性）衰减。慢性乙醇处理后回避任务的缺陷可以通过增加乙醇剂量来克服。2.氟马西尼，苯二氮卓类拮抗剂，也促进收购的回避反应在对照组大鼠。这种反应氟马西尼显着减少，在退出长期乙醇治疗。在戒断过程中，这种减少的回避反应也可以通过增加氟马西尼的剂量来克服。3.苯二氮卓类反向激动剂RO 15-4513产生回避反应缺陷，乙醇和氟马西尼以剂量相关方式拮抗该缺陷。4.为了确定氟马西尼是否具有苯二氮卓类激动剂的性质，已确定氟马西尼与苯二氮卓类氯氮卓不同，不会增强乙醇诱导的空中翻正反射缺陷。此外，氟马西尼在该程序中阻断了利血平的作用，与氟马西尼的苯二氮卓类拮抗剂作用一致。5.收集的数据是一致的假设，即一种内源性物质的苯二氮卓类反激动剂的特性拮抗急性给药乙醇的抗冲突行动在退出慢性乙醇暴露。
1. Acquisition of a two-way shuttle-box avoidance response is facilitated by ethanol. This facilitated acquisition of an avoidance response to ethanol was attenuated during withdrawal from chronic-ethanol diet intake (i.e. tolerance developed by ethanol). The deficit in the avoidance task after chronic ethanol treatment could be overcome by increasing the dose of ethanol. 2. Flumazenil, a benzodiazepine antagonist, also facilitated acquisition of the avoidance response in control rats. This response to flumazenil was significantly reduced during withdrawal from chronic-ethanol treatment. This reduced avoidance responding during withdrawal also could be overcome by increasing the dose of flumazenil. 3. The benzodiazepine-inverse agonist, RO 15-4513, produced a deficit in avoidance responding that was antagonized by both ethanol and flumazenil in a dose-related manner. 4. To determine whether flumazenil has the properties of a benzodiazepine agonist, it was established that, unlike the benzodiazepine chlordiazepoxide, flumazenil did not enhance the ethanol-induced deficit in the aerial righting reflex. Additionally, flumazenil blocked the action of chlordiazepoxide in this procedure, consistent with the benzodiazepine antagonist action of flumazenil. 5. Data collected are consistent with the hypothesis that an endogenous substance with the properties of a benzodiazepine-inverse agonist antagonizes the anticonflict actions of acutely administered ethanol during withdrawal from chronic-ethanol exposure.