Evidence for holistic episodic recollection via hippocampal pattern completion.
Evidence for holistic episodic recollection via hippocampal pattern completion.
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DOI：
10.1038/ncomms8462
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发表时间：
2015-07-02
影响因子：
16.6
通讯作者：
Burgess N
中科院分区：
文献类型：
--
作者：
Horner AJ;Bisby JA;Bush D;Lin WJ;Burgess N
回忆被认为是情景记忆的标志。在这里，我们提供的证据表明，海马体将形成事件的不同元素结合在一起，从而通过所有元素的模式完成来实现整体回忆。参与者从多个重叠的元素对中学习复杂的“事件”，并对所有成对关联进行测试。在编码时，元素“类型”（位置、人和物体/动物）在不同的新皮质区域产生激活，而海马活动则预测所有事件内对的记忆表现。当检索成对关联时，与所有事件元素相对应的新皮质活动都会恢复，包括那些与任务相关的活动。参与者偶然恢复的程度与其海马活动相关。我们的研究结果表明，在不同的新皮质区域中代表的事件元素在海马体中被绑定成连贯的“事件印迹”，从而通过海马模式完成和新皮质恢复的过程实现情景回忆——重新体验或整体检索事件的所有方面。 复杂事件记忆的整体检索被认为是情景记忆的标志。在这里，作者提供了行为和神经影像学证据，表明海马体将形成事件的元素结合在一起，通过所有元素的模式完成来允许整体的情景回忆。
Recollection is thought to be the hallmark of episodic memory. Here we provide evidence that the hippocampus binds together the diverse elements forming an event, allowing holistic recollection via pattern completion of all elements. Participants learn complex ‘events' from multiple overlapping pairs of elements, and are tested on all pairwise associations. At encoding, element ‘types' (locations, people and objects/animals) produce activation in distinct neocortical regions, while hippocampal activity predicts memory performance for all within-event pairs. When retrieving a pairwise association, neocortical activity corresponding to all event elements is reinstated, including those incidental to the task. Participant's degree of incidental reinstatement correlates with their hippocampal activity. Our results suggest that event elements, represented in distinct neocortical regions, are bound into coherent ‘event engrams' in the hippocampus that enable episodic recollection—the re-experiencing or holistic retrieval of all aspects of an event—via a process of hippocampal pattern completion and neocortical reinstatement. The holistic retrieval of complex event memories is thought to be the hallmark of episodic memory. Here, the authors provide behavioural and neuroimaging evidence that the hippocampus binds together the elements forming an event to allow holistic episodic recollection via pattern completion of all elements.