G-quadruplex recognition by macrocyclic hexaoxazole (6OTD) dimer.

G-quadruplex recognition by macrocyclic hexaoxazole (6OTD) dimer.
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DOI：
10.1093/nass/nrp117
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发表时间：
2009-09
期刊：
Nucleic acids symposium series
影响因子：
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通讯作者：
Keisuke Iida;Masayuki Tera;K. Shin‐ya;K. Nagasawa
Keisuke Iida;Masayuki Tera;K. Shin‐ya;K. Nagasawa
中科院分区：
其他
文献类型：
--
作者：
Keisuke Iida;Masayuki Tera;K. Shin‐ya;K. Nagasawa

文献摘要

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端粒酶抑素(TMS：1)是一种有效的、选择性的端粒G-四链结合蛋白。根据对接研究，建议将两个TMS分子插入到一个端粒G-四链中。本文设计合成了六恶唑TMS衍生物(6OTD)二聚体，并对其G-四链体稳定能力进行了评价。
Telomestatin (TMS: 1) is as a potent and selective telomeric G-quadruplex binder. Two molecules of TMS were suggested to be intercalated to one telomeric G-quadruplex according to docking study. In this paper, we designed and synthesized hexaoxazole TMS derivative (6OTD) dimer, and evaluated its G-quadruplex stabilizing ability.