Coordinate Transformation is First Completed Downstream of Primary Motor Cortex
Coordinate Transformation is First Completed Downstream of Primary Motor Cortex
复制标题
坐标变换首先在初级运动皮层的下游完成
作者：
Yuval Yanai;Nofya Adamit;Z. Israel;R. Harel;Y. Prut
之前有人提出，动作向基于肌肉的编码的转变是在初级运动皮层（M1）中完成的。这与从 M1 到运动神经元的主要直接途径一致。因此，位于 M1 下游的脊髓节段中间神经元预计会表现出类似肌肉的编码特性。我们通过同时记录灵长类动物的皮质和脊髓活动来解决这一假设，这些灵长类动物执行具有多个目标和两种手部姿势的等距手腕任务。在这里，我们表明，虽然运动皮层遵循中间坐标系，但脊髓中间神经元已经遵循类似肌肉的坐标系。因此，我们建议运动命令坐标转换的最后步骤通过皮质脊髓相互作用发生在 M1 下游。
It was suggested previously that the transformation of action to muscle-based coding is completed in the primary motor cortex (M1). This is consistent with a predominant direct pathway leading from M1 to motoneurons. Accordingly, spinal segmental interneurons that are located downstream to M1 are expected to show muscle-like coding properties. We addressed this hypothesis using simultaneous recording of cortical and spinal activity in primates performing an isometric wrist task with multiple targets and two hand postures. Here we show that while the motor cortex follows an intermediate coordinate frame, spinal interneurons already follow a muscle-like coordinate frame. We thus suggest that the final steps in coordinate transformation of motor commands take place downstream of M1 via corticospinal interactions.
影响因子：
56.9
作者：
GEORGOPOULOS, AP;LURITO, JT;MASSEY, JT
通讯作者：
MASSEY, JT
影响因子：
56.9
作者：
ANDERSEN, RA;ESSICK, GK;SIEGEL, RM
通讯作者：
SIEGEL, RM