Platelet P-selectin expression is associated with atherosclerotic wall thickness in carotid artery in humans
Platelet P-selectin expression is associated with atherosclerotic wall thickness in carotid artery in humans
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DOI：
10.1161/01.cir.0000081765.88440.51
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发表时间：
2003-08-05
期刊：
影响因子：
37.8
通讯作者：
Nishizawa, Y
中科院分区：
文献类型：
--
作者：
Koyama, H;Maeno, T;Nishizawa, Y
背景-最近的遗传动物模型揭示了血小板P-选择素在动脉粥样硬化进展中的重要作用。在本研究中，我们研究血小板P-选择素表达和动脉粥样硬化参数之间的关系在517 subjects.Methods和结果无关的主题（n = 517，235名男性和282名女性），包括187与2型糖尿病，184与高血压，和366与高脂血症，被纳入本研究。全血流式细胞术测定P-选择素表达。通过颈动脉超声测定动脉硬度（硬度指数β）和动脉壁厚度（内膜中层厚度[IMT]）。P-选择素表达与颈动脉IMT和僵硬指数β呈显著正相关。多元回归分析显示，P-选择素阳性血小板百分比与颈动脉IMT的相关性与其他临床因素无关。此外，P-选择素阳性血小板百分比在颈动脉斑块的受试者中更高，并且通过多元Logistic回归分析是颈动脉斑块发生的独立相关因素。最后，P-选择素阳性血小板的百分比与年龄，体重指数，收缩压和舒张压，和HbA 1c呈正相关，与HDL cholesterole.Conclusions-Platelet P-选择素是独立相关的动脉粥样硬化动脉壁的变化在人类受试者。
Background-Recent genetic animal models reveal important roles of platelet P-selectin on progression of atherosclerosis. In the present study, we examine the relation between platelet P-selectin expression and atherosclerotic parameters in 517 subjects.Methods and Results-Unrelated subjects (n = 517; 235 male and 282 female), including 187 with type 2 diabetes, 184 with hypertension, and 366 with hyperlipidemia, were enrolled in the study. P-selectin expression was determined by whole-blood flow cytometry. Arterial stiffness (stiffness index beta) and arterial wall thickness (intima-media thickness [IMT]) were determined by carotid ultrasound. P-selectin expression was significantly and positively correlated with carotid IMT and stiffness index beta. Multiple regression analyses showed that the association of the percentage of P-selectin-positive platelets with carotid IMT was independent of other clinical factors. Moreover, the percentage of P-selectin-positive platelets was higher in subjects with carotid plaque and was an independent factor associated with occurrence of carotid plaque analyzed by multiple logistic regression analysis. Finally, the percentage of P-selectin positive platelets was positively associated with age, body mass index, systolic and diastolic blood pressure, and HbA1c and inversely associated with HDL cholesterol.Conclusions-Platelet P-selectin is independently associated with atherosclerotic arterial wall changes in human subjects.