Intestinal fluid volumes and transit of dosage forms as assessed by magnetic resonance imaging
Intestinal fluid volumes and transit of dosage forms as assessed by magnetic resonance imaging
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DOI：
10.1111/j.1365-2036.2005.02683.x
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发表时间：
2005-11-01
影响因子：
7.6
通讯作者：
Weitschies, W
中科院分区：
文献类型：
--
作者：
Schiller, C;Fröhlich, CP;Weitschies, W
目的：用磁共振成像技术研究连续给药胶囊的胃肠转运与肠道液体利用率的关系。方法：对12名健康受试者空腹和餐后1h进行水敏感磁共振成像。结果：虽然食物摄入量降低了小肠的平均液体容量(105±/-72mLvs.54+/-41mL，P<；0.01)，但对结肠的平均液体容量(13+/-12mLvs.18+/-26mL)没有显著影响。餐后两个脏器的平均分离液囊数目增加(小肠：4对6，P<0.05；大肠：4对6，P<；0.05)。胶囊在小肠和大肠之间的分布受食物的影响很大(结肠：3粒，17粒，P<；0.01)。结论：液体在肠道中的分布不均匀，这可能是药物吸收个体差异的原因。此外，液体和固体物质通过回盲瓣的运输显然是由进餐引起的胃回盲部反射启动的。
Aim: The gastrointestinal transit of sequentially administered capsules was investigated in relation to the availability of fluid along the intestinal lumen by magnetic resonance imaging.Methods: Water-sensitive magnetic resonance imaging was performed on 12 healthy subjects during fasting and 1 h after a meal. Specifiable non-disintegrating capsules were administered at 7, 4 and 1 h prior to imaging.Results: While food intake reduced the mean fluid volumes in the small intestine (105 +/- 72 mL vs. 54 +/- 41 mL, P < 0.01) it had no significant effect on the mean fluid volumes in the colon (13 +/- 12 mL vs. 18 +/- 26 mL). The mean number of separated fluid pockets increased in both organs after meal (small intestine: 4 vs. 6, P < 0.05; large intestine: 4 vs. 6, P < 0.05). The distribution of capsules between the small and large intestine was strongly influenced by food (colon: 3 vs. 17 capsules, P < 0.01).Conclusions: The results show that fluid is not homogeneously distributed along the gut, which likely contributes to the individual variability of drug absorption. Furthermore, transport of fluid and solids through the ileocaecal valve is obviously initiated by a meal-induced gastro-ileocaecal reflex.