Correlation between estrogen receptor β expression and the curative effect of endocrine therapy in breast cancer patients.
Correlation between estrogen receptor β expression and the curative effect of endocrine therapy in breast cancer patients.
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DOI：
10.3892/etm.2014.1634
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发表时间：
2014-06
影响因子：
2.7
通讯作者：
Yilamu D
中科院分区：
文献类型：
--
作者：
Guo L;Zhang Y;Zhang W;Yilamu D
本研究旨在探讨乳腺癌患者雌激素受体β（ER β）表达水平与内分泌治疗疗效的关系。从2000年1月至2010年12月期间收集了583名乳腺癌患者的癌组织并用于分析。免疫组化法检测ERβ表达水平。生存分析采用Kaplan-Meier法，生存时间差异分析采用log-rank检验。此外，还进行了考克斯多因素分析，以分析乳腺癌的预后因素。免疫组化染色结果显示，ERβ阳性表达率<10%为ERβ低表达，>10%为ERβ高表达。在表达低水平ERβ的患者中，接受内分泌治疗的患者的中位无瘤生存时间显著高于未接受内分泌治疗的患者。相比之下，在ERβ高表达水平的患者中，接受内分泌治疗的患者与未接受内分泌治疗的患者之间的中位无瘤生存时间无显著差异。此外，与ERβ低表达患者相比，ERβ高表达患者的中位无瘤生存时间显著降低。ERβ表达、人表皮生长因子受体2表达、肿瘤大小、淋巴结转移、术后化疗、放疗和内分泌治疗是乳腺癌的独立预后因素。因此，乳腺癌中ERβ高表达提示内分泌治疗预后不良。
The aim of the present study was to investigate the association between the expression levels of estrogen receptor (ER)β and the curative effect of endocrine therapy in breast cancer patients. Cancer tissues were collected from 583 breast cancer patients between January 2000 and December 2010 and used for analysis. ERβ expression levels were determined using immunohistochemical staining. The Kaplan-Meier method was used for survival analysis and the log-rank test was conducted for difference analysis between survival times. In addition, Cox multivariate analysis was performed to analyze prognostic factors for breast cancer. In the immunohistochemical staining assay, a positive ERβ expression rate of <10% was defined as ERβ low expression, while >10% was defined as ERβ high expression. In patients expressing low levels of ERβ, the median tumor-free survival time of the patients who received endocrine therapy was significantly higher compared with that of the patients who did not receive endocrine therapy. By contrast, in patients with high ERβ expression levels, there was no significant difference in the median tumor-free survival time between the patients who received endocrine therapy and those who did not. In addition, compared with ERβ low expression patients, ERβ high expression patients had a significantly lower median tumor-free survival time. Furthermore, ERβ expression, human epidermal growth factor receptor 2 expression, tumor size, lymph node metastasis, postoperative chemotherapy, radiotherapy and endocrine therapy were identified to be independent prognostic factors for breast cancer. Therefore, high ERβ expression in breast cancer indicates poor prognosis for endocrine therapy.
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影响因子：
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