Catecholamines and diagnoses in children.
Catecholamines and diagnoses in children.
复制标题
儿茶酚胺和儿童诊断。
DOI：
10.1097/00004583-199003000-00012
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发表时间：
1990
影响因子：
13.3
通讯作者：
Macedo,CA
中科院分区：
文献类型：
--
作者：
Rogeness,GA;Javors,MA;Maas,JW;Macedo,CA
从理论上讲，去甲肾上腺素能（NA）功能可能是较低的受试者与社会化不足的行为障碍（CDU）和较高的受试者与焦虑/抑郁症。为了检验这一假设，比较了血浆多巴胺-β-羟化酶（DβH）活性低于6 μmoles/min/L（低DβH组）和大于15 μmoles/min/L（高Dβ H组）的受试者之间的诊断和24小时尿儿茶酚胺测量值。低DβH组与去甲肾上腺素代谢有关的几项指标较低，低DβH组有较多的CDU诊断，较少的焦虑和抑郁障碍诊断。每个DβH组的临床和生物学指标之间的比较也与NA功能、CDU和焦虑/抑郁障碍之间的假设关系一致。
Theoretically, noradrenergic (NA) function may be lower in subjects with undersocialized conduct disorder (CDU) and higher in subjects with anxiety/depressive disorder. To test this hypothesis, diagnostic and 24-hour urine catecholamine measures were compared between subjects with plasma dopamine-β-hydroxylase (DβH) activities less than 6 μmoles/min/L(low DβH group) and greater than 15 μmoles/min/L(high DβH group). Several measures relating to norepinephrine metabolism were lower in the low DβH group, and the low DβH group had more diagnoses of CDU and fewer anxiety and depressive disorder diagnoses. Comparisons between clinical and biological measures within each of the DβH groups were also consistent with the hypothesized relationship between NA function, CDU, and anxiety/depressive disorder.