Expression of membrane type 1-matrix metalloproteinase in laryngeal carcinoma.
Expression of membrane type 1-matrix metalloproteinase in laryngeal carcinoma.
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DOI：
10.1053/paor.1999.0217
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发表时间：
1999-01-01
期刊：
影响因子：
--
通讯作者：
Du, B
中科院分区：
文献类型：
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作者：
Du, B;Wang, P;Du, B
膜 1 型基质金属蛋白酶 (MT1-MMP) 是基质金属蛋白酶 (MMP) 家族中最近发现的独特膜型亚组的成员。 MT1-MMP 对细胞外基质成分具有蛋白水解活性，并激活细胞表面的原明胶酶 A (MMP-2)。本研究通过RT-PCR分析了45例喉癌组织中MT1-MMP mRNA的表达情况，并探讨了18例喉癌组织中MT1-MMP表达与生存的关系。结果显示，肿瘤组织中MT1-MMP mRNA的表达量高于相应的正常组织。临床III期的肿瘤表达高于II期。淋巴结转移患者的肿瘤MT1-MMP mRNA表达水平显着高于淋巴结阴性患者。高表达水平的患者的5年生存率显着低于低表达水平的患者。总的来说，我们的研究结果表明MT1-MMP的高水平表达与喉癌的侵袭和转移密切相关，并且预示着较差的预后。
Membrane type 1-matrix metalloproteinase (MT1-MMP) is a member of the recently identified unique membrane-type subgroup in the matrix metalloproteinase (MMP) family. MT1-MMP has proteolytic activity against components of the extracellular matrix and activates progelatinase A (MMP-2) at the cell surface. In this study, we analyzed the expression of MT1-MMP mRNA in 45 cases of laryngeal carcinoma by RT-PCR and investigated the relationship between MT1-MMP expression and survival in 18 cases. The result showed that the expression of MT1-MMP mRNA was higher in tumor tissue than in corresponding normal tissue. The tumoral expression in clinical stage III was higher than in stage II. The tumoral expression level of MT1-MMP mRNA in patients with lymph node metastasis was signigicantly higher than those with negative lymph nodes. The patients with high expression level showed significantly poorer 5 year survival than those with low expression level. Collectively, our findings suggest that the high level of MT1-MMP expression is closely related to the invasion and metastasis of laryngeal carcinoma, and indicates poorer prognosis.