MELATONIN INHIBITION OF NEONATAL PITUITARY RESPONSE TO LUTEINIZING HORMONE-RELEASING FACTOR
MELATONIN INHIBITION OF NEONATAL PITUITARY RESPONSE TO LUTEINIZING HORMONE-RELEASING FACTOR
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DOI：
10.1126/science.1108199
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发表时间：
1976-01-01
期刊：
影响因子：
56.9
通讯作者：
KLEIN, DC
中科院分区：
文献类型：
--
作者：
MARTIN, JE;KLEIN, DC
在器官培养中加入1纳摩尔黄体生成素释放因子(LRF)的新生大鼠脑垂体中黄体生成素(LH)浓度比对照组增加了10倍。同时用1纳摩尔褪黑素处理腺体，可显著降低LRF对促黄体生成激素的刺激作用。这一发现表明，褪黑素可以直接作用于新生儿脑垂体，抑制LRF对促黄体生成素的反应。
Neonatal rat anterior pituitary glands treated in organ culture with 1 nanomolar luteinizing hormone-releasing factor (LRF) showed a tenfold increase in medium luteinizing hormone (LH) concentrations over control values. Simultaneous treatment of the glands with 1 nanomolar melatonin significantly reduced the stimulatory effect of LRF on release of LH. This finding indicates that melatonin can act directly on the neonatal pituitary to inhibit the LH response to LRF.