HLA ANTIGENS IN JAPANESE PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS
HLA ANTIGENS IN JAPANESE PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS
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DOI：
10.3109/03009749409103059
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发表时间：
1994-01-01
影响因子：
2.1
通讯作者：
HIROSE, S
中科院分区：
文献类型：
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作者：
HASHIMOTO, H;NISHIMURA, Y;HIROSE, S
为了确定 HLA 抗原与 SLE 的关联以及该疾病的临床表现，我们对 58 名符合 ARA 诊断标准的日本 SLE 患者以及 97 名正常对照者进行了 HLA 抗原检测。使用第 11 届 HLA 研讨会提供的抗血清对 HLA I 类和 II 类抗原进行血清学分型。在 HLA II 类抗原中，使用 PCR/SSOP 方法通过 DNA 分型进一步定义了 DRB、DQ 和 DP 等位基因。具有HLA-B39、DRB1*1501、DRB5*0101和DQB1*0602的SLE患者明显多于正常对照。该结果表明HLA-DRB 1*1501-DRB5*0101-DQA1*0102-DQB1*0602的单倍型由日本的SLE相关MHC标记组成。 HLA 抗原与 SLE 的临床或血清学结果之间存在一些正相关和负相关。某些 HLA 等位基因可能与 SLE 的临床和/或血清学亚型有关。
To determine the association of HLA antigens with SLE and the clinical findings of the disease, HLA antigens were tested in 58 Japanese patients with SLE, who fulfilled the ARA diagnostic criteria, along with 97 normal controls. HLA class I and II antigens were typed serologically using the antisera provided by the 11th HLA Workshop. Among the HLA class II antigens, further DRB, DQ and DP alleles were defined by DNA typing using the PCR/SSOP method. There were significantly more SLE patients with HLA-B39, DRB1*1501, DRB5*0101 and DQB1*0602 than normal controls. This result suggested that the haplotype of HLA-DRB 1*1501-DRB5*0101-DQA1*0102-DQB1*0602 consists of the SLE-associated MHC markers in Japan. There were some positive and negative associations between the HLA antigens and clinical or serological findings in SLE. There is a possibility that some HLA alleles might be related to the clinical and/or serological subsets of SLE.