Exploring the feasibility of obtaining mifepristone and misoprostol from the internet
Exploring the feasibility of obtaining mifepristone and misoprostol from the internet
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DOI：
10.1016/j.contraception.2017.09.016
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发表时间：
2018-04-01
期刊：
影响因子：
2.9
通讯作者：
Winikoff, Beverly
中科院分区：
文献类型：
--
作者：
Murtagh, Chloe;Wells, Elisa;Winikoff, Beverly
目的：我们的目的是记录从网上供应商购买堕胎药的经验，不需要处方，并评估收到的药丸的活性成分含量。研究设计：我们在互联网上搜索，以确定一个方便的样本网站出售米非司酮和米索前列醇在美国的购买者，并试图订购这些产品。我们记录了价格，运输时间和订购的其他方面。我们将收到的样品送到检测实验室，测量单个片剂中活性成分的含量。结果：我们确定了18个网站，订购了22种产品：20种米非司酮米索前列醇组合产品和2种仅含米索前列醇的产品。我们从16个不同的研究中心收到了18种复方制剂和2种米索前列醇制剂。没有研究中心需要处方或任何相关的医疗信息。这20种产品从订购到收到的时间为3至21个工作日（中位数为9.5天）。18种组合产品的价格从110美元到360美元不等，包括运费和费用;不含米非司酮的产品成本较低。化学分析发现，18片标示为200 mg米非司酮的片剂含有184.3 mg至204.1 mg米非司酮，而20片标示为200微克的米索前列醇含有34.1微克和201.4微克之间的活性成分。结论：在美国，从在线医药网站获得堕胎药物是可行的。收到的米非司酮片中活性成分的含量在标示量的8%以内。米索前列醇片都含有这种化合物，但通常少于标签。(C)2017作者爱思唯尔公司出版
Objectives: We aimed to document the experience of buying abortion pills from online vendors that do not require a prescription and to evaluate the active ingredient content of the pills received.Study design: We searched the internet to identify a convenience sample of websites that sold mifepristone and misoprostol to purchasers in the United States and attempted to order these products. We documented price, shipping time and other aspects of ordering. We sent the samples received to a testing laboratory that measured the amount of active ingredient in individual tablets.Results: We identified 18 websites and ordered 22 products: 20 mifepristone misoprostol combination products and 2 that contained only misoprostol. We received 18 combination products and the 2 misoprostol products from 16 different sites. No site required a prescription or any relevant medical information. The time between order and receipt of the 20 products ranged from 3 to 21 business days (median 9.5 days). The price for the 18 combination products ranged from $110 to $360, including shipping and fees; the products without mifepristone cost less. Chemical assays found that the 18 tablets labeled 200 mg mifepristone contained between 184.3 mg and 204.1 mg mifepristone, while the 20 tablets labeled 200 mcg misoprostol contained between 34.1 mcg and 201.4 mcg of the active ingredient.Conclusions: Obtaining abortion medications from online pharmaceutical websites is feasible in the United States. The mifepristone tablets received contained within 8% of the labeled amount of active agent. The misoprostol tablets all contained that compound but usually less than labeled. (C) 2017 The Authors. Published by Elsevier Inc.