SEX-DIFFERENCES IN ANIMAL TESTS OF ANXIETY
SEX-DIFFERENCES IN ANIMAL TESTS OF ANXIETY
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DOI：
10.1016/0031-9384(91)90039-q
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发表时间：
1991-02-01
影响因子：
2.9
通讯作者：
FILE, SE
中科院分区：
文献类型：
--
作者：
JOHNSTON, AL;FILE, SE
为了进一步探讨旷场实验中性二态行为的意义，对雄性和雌性帽衫李斯特大鼠进行了三次焦虑实验。 在社会互动测试中，雌性大鼠的社会互动分数较低，并且在熟悉该装置后不像雄性大鼠那样容易增加。 在高架十字迷宫实验中，雌性大鼠对开放臂的厌恶程度低于雄性大鼠;在改良Vogel冲突实验中，雌性大鼠的惩罚性舔舔率低于雄性大鼠。 得出的结论是，在这些测试中，雄性和雌性大鼠的行为不同，但不能得出关于焦虑水平性别差异的确切结论，因为所有三个测试都没有导致相同方向的预测。 也有人建议，谨慎的解释是必要的，因为这些测试可以测量不同的变量在雄性和雌性大鼠，他们可能不是有效的测试焦虑的雌性大鼠。
To explore further the meaning of sexually dimorphic behavior in the open-field test, male and female hooded Lister rats were tested in three tests of anxiety. In the social interaction test, the social interaction scores of the female rats were lower and did not increase as readily following familiarization to the apparatus as those of the male rats. In the elevated plus-maze test, female rats showed a reduced aversion to the open arms compared to male rats; and in a modified Vogel conflict test, the punished licking rates of the female rats were lower than those of the male rats. It is concluded that the behavior of male and female rats differs in these tests, but that firm conclusions concerning sex differences in anxiety levels cannot be made because all three tests did not lead to predictions which were in the same direction. It is also suggested that cautious interpretation is necessary because these tests may measure different variables in male and female rats and they may not be valid tests of anxiety for female rats.