Hydrogen Peroxide in Exhaled Breath Condensate in Patients with Asthma A Promising Biomarker?
Hydrogen Peroxide in Exhaled Breath Condensate in Patients with Asthma A Promising Biomarker?
复制标题
哮喘患者呼出气冷凝物中的过氧化氢是一个有前途的生物标志物吗？
DOI：
10.1378/chest.10-2816
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发表时间：
2011-07-01
期刊：
影响因子：
9.6
通讯作者：
Barnes, Peter J.
中科院分区：
文献类型：
--
作者：
Teng, Yue;Sun, Peili;Barnes, Peter J.
背景资料：呼出气冷凝液（EBC）中过氧化氢（H2 O2）的测量已被提出作为监测气道炎症的非侵入性方法。然而，EBC H2 O2评估哮喘的个体研究结果相互矛盾。本研究的目的是探讨EBC H2 O2是否升高的人与哮喘，它是否反映了疾病的严重程度和疾病控制或响应皮质类固醇treatment.Methods：研究通过检索PubMed，Embase，科克伦数据库，累积索引护理和相关健康文献（CINAHL），和vvww.controlled-trials.com 2010年9月之前发表的相关报告。纳入了比较非吸烟哮喘患者和健康受试者EBC H2 O2水平的观察性研究。数据由两名研究者独立提取，并使用Stata 10.0软件进行分析。与健康受试者相比，不吸烟的哮喘患者的EBC H2 O2浓度显著较高，并且在按严重程度或对照水平分类的每个哮喘水平上观察到较高的EBC H2 O2值，并且该值与FEV 1呈负相关。结论：H2 O2可能是一种有前途的指导哮喘治疗的生物标志物。然而，需要进一步调查以确定其作用。胸部2011; 140（1）：108-116
Background: The measurement of hydrogen peroxide (H2O2) in exhaled breath condensate (EBC) has been proposed as a noninvasive way of monitoring airway inflammation. However, results from individual studies on EBC H2O2 evaluation of asthma are conflicting. The purpose of this study was to explore whether EBC H2O2 is elevated in people with asthma and whether it reflects disease severity and disease control or responds to corticosteroid treatment.Methods: Studies were identified by searching PubMed, Embase, Cochrane Database, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and vvww.controlled-trials.com for relevant reports published before September 2010. Observational studies comparing levels of EBC H2O2 between patients with asthma who were nonsmokers and healthy subjects were included. Data were independently extracted by two investigators and analyzed using Stata 10.0 software.Results: Eight studies (involving 728 participants) were included. EBC H2O2 concentrations were significantly higher in patients with asthma who were nonsmokers compared with healthy subjects, and higher values of EBC H2O2 were observed at each level of asthma, classified either by severity or control level, and the values were negatively correlated with FEV1. In addition, EBC H2O2 concentrations were lower in patients with asthma treated with corticosteroids than in patients with asthma not treated with corticosteroids.Conclusions: H2O2 might be a promising biomarker for guiding asthma treatment. However, further investigation is needed to establish its role. CHEST 2011; 140(1):108-116