Can Autologous Platelet-Rich Plasma Gel Enhance Healing After Surgical Extraction of Mandibular Third Molars?
Can Autologous Platelet-Rich Plasma Gel Enhance Healing After Surgical Extraction of Mandibular Third Molars?
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DOI：
10.1016/j.joms.2011.02.014
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发表时间：
2011-09-01
影响因子：
1.9
通讯作者：
Owotade, Folusho J.
中科院分区：
文献类型：
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作者：
Ogundipe, Olufemi K.;Ugboko, Vincent I.;Owotade, Folusho J.
目的：本次调查评估的效果富血小板血浆（PRP）凝胶术后疼痛，肿胀，牙关紧闭，以及愈合和骨再生潜力对下颌第三磨牙提取sockets.Patients和方法：一个前瞻性的随机比较临床研究进行了2年的时间。招募了需要手术拔除单个阻生第三磨牙且符合入选标准并表示愿意返回进行回忆访视的患者。预测变量是在试验组中将PRP凝胶应用于第三磨牙的牙槽，而对照组没有PRP。结果变量为疼痛、肿胀和最大张口度，分别使用10分视觉模拟量表、卷尺和毫米卡尺测量。通过分配硬脑膜、整体密度和骨小梁模式的评分，通过放射学评估骨槽愈合。定量数据表示为平均值。使用Mann-Whitney检验比较连续变量的组间平均值，而使用Fischer精确检验比较分类变量。结果：60例患者年龄19 ~ 35岁（平均24.7 ± 3.6岁），分为试验组和对照组，每组30例。PRP组在所有时间点的平均术后疼痛评分（视觉模拟量表）均较低，具有统计学显著性（P < .05）。尽管试验组的肿胀和切间开口的数值较低，但该差异无统计学显著性。同样，PRP组患者的硬脑膜、骨小梁模式和骨密度评分更好。这种差异也没有统计学意义。结论：PRP组记录减少疼痛，肿胀，牙关紧闭，以及增强和更快的骨愈合与对照组相比。因此，研究表明，局部应用PRP凝胶对第三磨牙手术后促进牙槽愈合具有有益作用。(C)2011年美国口腔颌面外科医师协会J Oral Maxillofac Surg 69：2305-2310，2011
Purpose: This investigation assesses the effect of platelet-rich plasma (PRP) gel on postoperative pain, swelling, and trismus as well as healing and bone regeneration potential on mandibular third molar extraction sockets.Patients and Methods: A prospective randomized comparative clinical study was undertaken over a 2-year period. Patients requiring surgical extraction of a single impacted third molar and who fell within the inclusion criteria and indicated willingness to return for recall visits were recruited. The predictor variable was application of PRP gel to the socket of the third molar in the test group, whereas the control group had no PRP. The outcome variables were pain, swelling, and maximum mouth opening, which were measured using a 10-point visual analog scale, tape, and millimeter caliper, respectively. Socket healing was assessed radiographically by allocating scores for lamina dura, overall density, and trabecular pattern. Quantitative data were presented as mean. Mann-Whitney test was used to compare means between groups for continuous variables, whereas Fischer exact test was used for categorical variables. Statistical significance was inferred at P < .05.Results: Sixty patients aged 19 to 35 years (mean: 24.7 +/- 3.6 years) were divided into both test and control groups of 30 patients each. The mean postoperative pain score (visual analog scale) was lower for the PRP group at all time points and this was statistically significant (P < .05). Although the figures for swelling and interincisal mouth opening were lower in the test group, this difference was not statistically significant. Similarly, the scores for lamina dura, trabecular pattern, and bone density were better among patients in the PRP group. This difference was also not statistically significant.Conclusion: The PRP group recorded reduced pain, swelling, and trismus as well as enhanced and faster bone healing compared with those in the control. Hence the study showed that topical application of PRP gel has a beneficial effect in enhancing socket healing after third molar surgery. (C) 2011 American Association of Oral and Maxillofacial Surgeons J Oral Maxillofac Surg 69:2305-2310, 2011