Cuprizone inhibits demyelinating leukomyelitis by reducing immune responses without virus exacerbation in an infectious model of multiple sclerosis
Cuprizone inhibits demyelinating leukomyelitis by reducing immune responses without virus exacerbation in an infectious model of multiple sclerosis
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DOI：
10.1016/j.jneuroim.2012.01.010
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发表时间：
2012-03-01
影响因子：
3.3
通讯作者：
Beineke, Andreas
中科院分区：
文献类型：
--
作者：
Herder, Vanessa;Hansmann, Florian;Beineke, Andreas
多发性硬化症是年轻人中最常见的脱髓鞘中枢神经系统疾病之一。Theiler小鼠脑脊髓炎（TME）是广泛使用的用于人类髓鞘疾病的病毒诱导的小鼠模型。免疫抑制方法通常会降低抗病毒免疫力，因此会增加病毒传播并伴有临床恶化。在本研究中，TME的进展过程中显着延迟，由于五周的cuprizone喂养期。Cuprizone能够最大限度地减少脱髓鞘性白血病，而不会使病毒恶化。这种现象被认为是选择性抑制有害炎症反应的结果，同时保持对病毒的保护性免疫。(C)2012爱思唯尔有限公司版权所有。
Multiple sclerosis is one of the most common demyelinating central nervous system diseases in young adults. Theiler's murine encephalomyelitis (TME) is a widely used virus-induced murine model for human myelin disorders. Immunosuppressive approaches generally reduce antiviral immunity and therefore increase virus dissemination with clinical worsening. In the present study, the progressive course of TME was significantly delayed due to a five-week cuprizone feeding period. Cuprizone was able to minimize demyelinating leukomyelitis without virus exacerbation. This phenomenon is supposed to be a consequence of selective inhibition of detrimental inflammatory responses with maintained protective immunity against the virus. (C) 2012 Elsevier B.V. All rights reserved.