Phoenixin-14 concentrations are increased in association with luteinizing hormone and nesfatin-1 concentrations in women with polycystic ovary syndrome
Phoenixin-14 concentrations are increased in association with luteinizing hormone and nesfatin-1 concentrations in women with polycystic ovary syndrome
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多囊卵巢综合征女性中 Phoenixin-14 浓度升高与黄体生成素和 nesfatin-1 浓度相关
DOI：
10.1016/j.cca.2017.06.013
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发表时间：
2017-08-01
影响因子：
5
通讯作者：
Sheng, Jian-Zhong
中科院分区：
文献类型：
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作者：
Ullah, Kamran;Rahman, Tanzil Ur;Sheng, Jian-Zhong
背景：多囊卵巢综合征（PCOS）是一种以肥胖、胰岛素抵抗（IR）、高雄激素血症和多毛症为特征的常见疾病.本研究旨在探讨大鼠下丘脑-垂体-性腺轴（hypothalamic-pituitary-gonadal axis，HPH-14（a）中凤凰素-14（phoenixin-14（a）与性激素（LH、FSH、E_2、FSH、LH、FSH、E_2、E_3、E_4、E_6、E_8、E_9、E_10、E_11、E_12、E_13、E_14、方法：采用鹿特丹标准对41例PCOS患者和37例健康对照者进行血清孕酮（P-4）和总睾酮（TT）水平的测定。PCOS患者血清凤凰素-14浓度为0.515 ± 0.044 ng/ml，显著高于健康对照组（0.289 ± 0.046 ng/ml，n = 37）。PCOS患者血清LH、脱氢表雄酮、空腹血糖水平及胰岛素抵抗指数均高于正常对照组。相关分析显示，phoenixin-14与LH、FSH、TT、P-4、BMI和nesfatin-1浓度呈显著正相关，与E2和血清胰岛素（FSI）浓度呈显著负相关。phoenixin-14浓度与LH和TT浓度的正相关性表明phoenixin-14在PCOS的发展中可能起作用。
Background: Polycystic ovary syndrome (PCOS) is commonly characterized by obesity, insulin resistance (IR), hyperandrogenemiaand hirsutism. Following the reported relationship between phoenixin-14 (a)nd gonadotropin production in rat hypothalamic-pituitary-gonadal axis, the present study was designed to investigate the circulating concentrations of phoenixin-14 and their associations with the concentrations of sex hormones including luteinizing hormone (LH), follicular stimulating hormone (FSH), estradiol (E2), progesterone (P-4) and total testosterone (TT) in PCOS patients.Methods: A total of 41 women with diagnosed PCOS using Rotterdam criteria and 37 healthy individuals were enrolled in the study.Results: Serum phoenixin-14 concentration in PCOS patients (it = 41) was 0.515 +/- 0.044 ng/ml, significantly higher than that in healthy controls (0.289 +/- 0.046 ng/ml, n = 37). PCOS patients had higher serum LH, dehydroepiandrosterone and fasting blood glucose concentrations, and higher index of homeostasis model of assessment-IR than those in healthy women. Correlation analysis showed significantly positive correlations of phoenixin-14 with LH, FSH, TT, P-4, BMI and nesfatin-1 concentrations, and significantly negative correlations with E2 and serum insulin (FSI) concentrations, respectively.Conclusions: Compared to control women, PCOS patients had significantly increased serum phoenixin-14, LH and androgen concentrations. The positive correlations of phoenixin-14 concentrations with LH and TT concentrations suggest a possible role of phoenixin-14 in the development of PCOS.