Diversity of septin scaffolds
Diversity of septin scaffolds
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DOI：
10.1016/j.ceb.2005.12.005
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发表时间：
2006-02-01
影响因子：
7.5
通讯作者：
Kinoshita, M
中科院分区：
文献类型：
--
作者：
Kinoshita, M
胞膜蛋白是普遍存在的GTP结合蛋白，通常被认为是细胞骨架组分。以酵母Septin领为代表的高阶Septin组装体作为细胞骨架，为许多细胞因子提供结构支持和支架。然而，在后生动物中，典型的高阶septin组件往往不如分散的“低阶”septin人口占主导地位。最近的研究表明，没有明显的结构，以前逃脱了我们的注意septin人口作为骨架的动粒马达蛋白和螯合仓库微管调节。与形成均匀、连续网络的经典细胞骨架聚合物不同，septin聚合物是多样的、不连续的和相对静止的，似乎适合于形成离散的支架。因此，隔蛋白系统可能被重新定义为离散的支架，有条件地联合起来表现得像细胞骨架。
Septins are ubiquitous GTP-binding proteins generally regarded as cytoskeletal components. Higher-order septin assemblies represented by the yeast septin collar function as cytoskeleton, providing structural support and scaffolds for many cellular factors. In metazoans, however, typical higher-order septin assemblies are often less predominant than dispersed 'low-order' septin populations. Recent studies revealed that septin populations with no obvious structure that had previously escaped our attention serve as scaffolds for kinetochore motor proteins and as sequestering depots for microtubule regulators. Unlike classic cytoskeletal polymers, which form uniform, continuous networks, septin polymers, being diverse, discontinuous and relatively static, seem suited to form discrete scaffolds. Thus, the septin system might be redefined as discrete scaffolds that are conditionally united to behave like cytoskeleton.