Longitudinal study of moderate weight change and sleep-disordered breathing
Longitudinal study of moderate weight change and sleep-disordered breathing
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DOI：
10.1001/jama.284.23.3015
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发表时间：
2000-12-20
影响因子：
120.7
通讯作者：
Skatrud, J
中科院分区：
文献类型：
--
作者：
Peppard, PE;Young, T;Skatrud, J
背景 体重过重与睡眠呼吸障碍 (SDB) 呈正相关，睡眠呼吸障碍是美国普通人群中的一种普遍病症。尚未对 SDB 与体重变化之间的纵向关联进行大型研究。目的 测量体重变化与 SDB 严重程度变化之间的独立纵向关联。设计 1989 年 7 月至 2000 年 1 月进行的基于人群的前瞻性队列研究。背景和参与者 690 名随机选择的威斯康星州就业居民（基线平均年龄 46 岁；56% 男性），每 4 年进行两次 SDB 评估。主要结果指标相对于体重变化，呼吸暂停低通气指数（AHI；呼吸暂停事件 + 每小时睡眠呼吸暂停事件）的百分比变化以及发生中度至重度 SDB（定义为 AHI 大于或等于每小时睡眠 15 次事件）的几率。结果 相对于稳定体重，体重增加 10% 预测约为 32%（95% 置信区间 [CI]，20%-45%） AHI 增加，体重减轻 10% 预测 AHI 减少 26%（95% CI，18%-34%）。体重增加 10% 预示中度至重度 SDB 的发病几率会增加 6 倍（95% CI，2.2-17.0）。结论我们的数据表明，即使是适度的体重控制，临床和公共卫生计划也可能有效管理 SDB 并减少新发 SDB 的发生。
Context Excess body weight is positively associated with sleep-disordered breathing (SDB), a prevalent condition in the US general population. No large study has been conducted of the longitudinal association between SDB and change in weight.Objective To measure the independent longitudinal association between weight change and change in SDB severity.Design Population-based, prospective cohort study conducted from July 1989 to January 2000.Setting and Participants Six hundred ninety randomly selected employed Wisconsin residents (mean age at baseline, 46 years; 56% male) who were evaluated twice at 4-year intervals for SDB.Main Outcome Measures Percentage change in the apnea-hypopnea index (AHI; apnea events + hypopnea events per hour of sleep) and odds of developing moderate-to-severe SDB (defined by an AHI greater than or equal to 15 events per hour of sleep), with respect to change in weight.Results Relative to stable weight, a 10% weight gain predicted an approximate 32% (95% confidence interval [CI], 20%-45%) increase in the AHI, A 10% weight loss predicted a 26% (95% CI, 18%-34%) decrease in the AHI. A 10% increase in weight predicted a 6-fold (95% CI, 2.2-17.0) increase in the odds of developing moderate-to-severe SDB.Conclusions Our data indicate that clinical and public health programs that result in even modest weight control are likely to be effective in managing SDB and reducing new occurrence of SDB.