Estimation of paracetamol and aceclofenac in tablet formulation by ratio spectra derivative spectroscopy.
Estimation of paracetamol and aceclofenac in tablet formulation by ratio spectra derivative spectroscopy.
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DOI：
10.4103/0250-474x.45403
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发表时间：
2008-09
影响因子：
0.5
通讯作者：
Gandhi SV
中科院分区：
文献类型：
--
作者：
Nikam AD;Pawar SS;Gandhi SV
建立了一种灵敏、简便、快速、准确的同时测定复方制剂中对乙酰氨基酚和醋氯芬酸含量的新方法。该方法基于比值导数分光光度法。选择256 nm和268 nm（最小值）处比值光谱的一阶导数振幅，以测定复方制剂中的对乙酰氨基酚和醋氯芬酸。该方法具有良好的线性、准确度和重现性。通过统计学和回收率研究验证了分析结果。
A new sensitive, simple, rapid and precise method for simultaneous estimation of paracetamol and aceclofenac in combined tablet dosage form has been developed. The method is based on ratio derivative spectrophotometry. The amplitude in first derivative of the ratio spectra at 256 nm and 268 nm (minima) were selected to determine paracetamol and aceclofenac in combined formulation. The method showed good linearity, accuracy and reproducibility. Results of analysis were validated statistically and by recovery studies.