Relationship between consecutive deterioration of mean deviation value and progression of visual field defect in open-angle glaucoma
Relationship between consecutive deterioration of mean deviation value and progression of visual field defect in open-angle glaucoma
复制标题
开角型青光眼平均偏差值连续恶化与视野缺损进展的关系
作者：
Tomoko Naito;K. Yoshikawa;S. Mizoue;Mami Nanno;Tairo Kimura;H. Suzumura;Ryuji Takeda;Fumio Shiraga
目的 分析开角型青光眼（OAG）（包括原发性 OAG 和正常眼压性青光眼）平均偏差（MD）值连续恶化与青光眼视野（VF）进展之间的关系。患者和方法 研究对象是接受 OAG 治疗的患者，他们使用 Humphrey 场分析仪（SITA 标准，C30-2 程序）进行了至少 10 次 VF 测试。 VF 进展的定义是随访期间最后一次 VF 测试时 MD 斜率显着为负（MD 斜率恶化）。回顾性分析MD斜率恶化与MD值连续恶化之间的关系。结果 共纳入 165 名患者的 165 只眼睛进行分析。 72 名患者 (43.6%) 的 72 只眼睛观察到 VF 缺陷显着进展，而 93 名患者 (56.4%) 的 93 只眼睛没有明显进展。 MD值连续恶化的频率与MD斜率恶化之间存在显着关系（P<0.0001，Cochran-Armitage趋势检验）。在多重 Logistic 回归分析中，观察到 MD 值连续恶化 3 次（比值比：2.1，P=0.0224）和 4 次（比值比：3.6，P=0.0008）的眼睛与 MD 斜率恶化存在显着相关性，但与连续两次恶化的眼睛没有显着相关性（比值比：1.1，P=0.8282）。 VF进展眼眼压降低率显着降低（P<0.01）。结论 这项回顾性研究表明，MD 值连续三次或更多次恶化可能是 OAG 未来 MD 斜率显着恶化的预测因素。
Purpose To analyze the relationship between consecutive deterioration of mean deviation (MD) value and glaucomatous visual field (VF) progression in open-angle glaucoma (OAG), including primary OAG and normal tension glaucoma. Patients and methods The subjects of the study were patients undergoing treatment for OAG who had performed VF tests at least 10 times with a Humphrey field analyzer (SITA standard, C30-2 program). The VF progression was defined by a significantly negative MD slope (MD slope worsening) at the final VF test during the follow-up period. The relationship between the MD slope worsening and the consecutive deterioration of MD value were retrospectively analyzed. Results A total of 165 eyes of 165 patients were included in the analysis. Significant progression of VF defects was observed in 72 eyes of 72 patients (43.6%), while no significant progression was evident in 93 eyes of 93 patients (56.4%). There was significant relationship between the frequency of consecutive deterioration of MD value and MD slope worsening (P<0.0001, Cochran–Armitage trend test). A significant association was observed for MD slope worsening in the eyes with three (odds ratio: 2.1, P=0.0224) and four (odds ratio: 3.6, P=0.0008) consecutive deterioration of MD value in multiple logistic regression analysis, but no significant association in the eyes with two consecutive deterioration (odds ratio: 1.1, P=0.8282). The eyes with VF progression had significantly lower intraocular pressure reduction rate (P<0.01). Conclusion This retrospective study has shown that three or more consecutive deterioration of MD value might be a predictor to future significant MD slope worsening in OAG.
基于模式和总偏差的青光眼变化概率程序的比较。
DOI：
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发表时间：
2000
期刊：
Investigative ophthalmology & visual science.
影响因子：
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作者：
Katz,J
通讯作者：
Katz,J
影响因子：
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作者：
Heijl, A;Leske, MC;Hussein, M
通讯作者：
Hussein, M
影响因子：
13.7
作者：
Heijl, Anders;Bengtsson, Boel;Leske, M. Cristina
通讯作者：
Leske, M. Cristina