Formal synthesis of (±)-perhydrohistrionicotoxin via a stepwise [3+3] annelation strategy
Formal synthesis of (±)-perhydrohistrionicotoxin via a stepwise [3+3] annelation strategy
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DOI：
10.1016/j.tetlet.2005.11.015
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发表时间：
2006-01-16
影响因子：
1.8
通讯作者：
Harrity, JPA
中科院分区：
文献类型：
--
作者：
Provoost, OY;Hedley, SJ;Harrity, JPA
描述了(+/-)-过氢组氨酸毒素的正式合成，包括高度非对映选择性修饰的Sharpless叠氮化反应和用于立体选择性构建关键螺哌啶基序的逐步[3+3]环化反应。(c) 2005 Elsevier Ltd权利已尽。
A formal synthesis of (+/-)-perhydrohistrionicotoxin is described that includes a highly diastereoselective modified Sharpless aziridination and a stepwise [3+3] annelation reaction for the stereoselective construction of the key spiropiperidine motif. (c) 2005 Elsevier Ltd. All rights r6served.