The roles of histamine H1 receptors on cognition
The roles of histamine H1 receptors on cognition
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组胺 H1 受体对认知的作用
DOI：
10.1007/s00011-007-0620-4
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发表时间：
2008
影响因子：
6.7
通讯作者：
Takehiko Watanabe
中科院分区：
文献类型：
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作者：
Kazuhiko Yanai;H. Dai;E. Sakurai;Takehiko Watanabe
材料与方法实验1：在社会饲养的正常条件下，通过物体识别、巴恩斯迷宫和恐惧条件反射测试评估H1 KO小鼠的学习和记忆能力。这些行为任务依赖于前额叶皮层、海马或杏仁核的功能。此外，我们还研究了H1KO小鼠及其WT小鼠海马CA1区的长时程增强（LTP）。
Materials and methodsExperiment 1: Under socially-reared normal conditions, learning and memory were evaluated in H1KO mice by object recognition, Barnes maze and fear conditioning tests. These behavioral tasks are dependent on the function of prefrontal cortex, hippocampus or amygdala. Furthermore, we also examined long-term potentiation (LTP) in CA1 area of hippocampus in H1KO mice and their WT mice.