Distinct mechanisms for top-down control of neural gain and sensitivity in the owl optic tectum.

Distinct mechanisms for top-down control of neural gain and sensitivity in the owl optic tectum.
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自上而下控制神经增益和灵敏度的不同机制。

DOI:
10.1016/j.neuron.2008.09.013
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发表时间:
2008-11-26
期刊:
影响因子:
16.2
通讯作者:
Knudsen EI
Knudsen EI
中科院分区:
医学1区
文献类型:
--
作者:
Winkowski DE;Knudsen EI

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我们表明,自上而下的控制不同的机制调节,分别在猫头鹰的视顶盖(OT)的敏感性和获得的感觉反应。电微刺激在前脑凝视控制区,arcopalial凝视场(AGF),结果在OT的感觉反应的空间特异性调节。AGF微刺激增加了OT神经元的反应性,OT神经元代表与AGF部位相同位置的刺激。我们发现,这种效应的机制,运作局灶性增强神经元的敏感性,提高调谐的一致性和空间分辨率。同时,AGF微刺激降低了代表所有其他位置刺激的OT神经元的反应性。这种效应背后的机制在全球范围内调节神经元增益。这些不同机制的协调作用可以解释许多空间注意力对猴子神经反应和人类行为表现的影响。
We demonstrate that distinct mechanisms of top-down control regulate, respectively, the sensitivity and gain of sensory responses in the owl’s optic tectum (OT). Electrical microstimulation in the forebrain gaze-control area, the arcopallial gaze field (AGF), results in a space-specific regulation of sensory responses in the OT. AGF microstimulation increases the responsiveness of OT neurons representing stimuli at the same location as that represented at the AGF site. We show that the mechanism that underlies this effect operates focally to enhance neuronal sensitivity and to improve tuning consistency and spatial resolution. At the same time, AGF microstimulation decreases the responsiveness of OT neurons representing stimuli at all other locations. The mechanism that underlies this effect operates globally to modulate neuronal gain. The coordinated action of these different mechanisms can account for many of the reported effects of spatial attention on neural responses in monkeys and on behavioral performance in humans.
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