Distinct mechanisms for top-down control of neural gain and sensitivity in the owl optic tectum.
Distinct mechanisms for top-down control of neural gain and sensitivity in the owl optic tectum.
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自上而下控制神经增益和灵敏度的不同机制。
DOI:
10.1016/j.neuron.2008.09.013
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发表时间:
2008-11-26
期刊:
影响因子:
16.2
通讯作者:
Knudsen EI
中科院分区:
文献类型:
--
作者:
Winkowski DE;Knudsen EI
We demonstrate that distinct mechanisms of top-down control regulate, respectively, the sensitivity and gain of sensory responses in the owl’s optic tectum (OT). Electrical microstimulation in the forebrain gaze-control area, the arcopallial gaze field (AGF), results in a space-specific regulation of sensory responses in the OT. AGF microstimulation increases the responsiveness of OT neurons representing stimuli at the same location as that represented at the AGF site. We show that the mechanism that underlies this effect operates focally to enhance neuronal sensitivity and to improve tuning consistency and spatial resolution. At the same time, AGF microstimulation decreases the responsiveness of OT neurons representing stimuli at all other locations. The mechanism that underlies this effect operates globally to modulate neuronal gain. The coordinated action of these different mechanisms can account for many of the reported effects of spatial attention on neural responses in monkeys and on behavioral performance in humans.
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影响因子:
2.5
作者:
Dias, EC;Segraves, MA
通讯作者:
Segraves, MA
影响因子:
64.8
作者:
Herrero, J. L.;Roberts, M. J.;Delicato, L. S.;Gieselmann, M. A.;Dayan, P.;Thiele, A.
通讯作者:
Thiele, A.
DOI:
10.3758/bf03206794
发表时间:
1995-08-01
期刊:
PERCEPTION & PSYCHOPHYSICS
影响因子:
--
作者:
HOFFMAN, JE;SUBRAMANIAM, B
通讯作者:
SUBRAMANIAM, B
影响因子:
5.3
作者:
Maczko, Kristin A.;Knudsen, Phyllis F.;Knudsen, Eric I.
通讯作者:
Knudsen, Eric I.
影响因子:
64.8
作者:
Bala, ADS;Spitzer, MW;Takahashi, TT
通讯作者:
Takahashi, TT