Roles of p38 MAPKs in invasion and metastasis
Roles of p38 MAPKs in invasion and metastasis
复制标题
DOI：
10.1042/bst20110676
复制
发表时间：
2012-02-01
影响因子：
3.9
通讯作者：
Nebreda, Angel R.
中科院分区：
文献类型：
--
作者：
Barrantes, Ivan del Barco;Nebreda, Angel R.
来自原发肿瘤的细胞需要经过几个步骤才能完全转移。在这个过程中，癌细胞获得了侵袭、在周围组织中迁移、进入循环并在远处器官定居的能力。本文就p38MAPK(丝裂原活化蛋白激酶)信号通路如何参与肿瘤转移的不同环节进行综述。实验证据表明，肿瘤细胞需要调节p38MAPK活性水平才能成功转移。
Cells from primary tumours need to go through several steps to become fully metastatic. During this process, cancer cells acquire the ability to invade, migrate across the surrounding tissue, enter into the circulation and colonize distant organs. In the present paper, we review recent progress in understanding how the p38 MAPK (mitogen-activated protein kinase) signalling pathway participates in the different steps of metastasis. Experimental evidence suggests that tumour cells need to modulate p38 MAPK activity levels to successfully metastasize.