Protein array reveals differentially expressed proteins in subcutaneous adipose tissue in obesity
Protein array reveals differentially expressed proteins in subcutaneous adipose tissue in obesity
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DOI：
10.1038/oby.2007.285
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发表时间：
2007-10-01
期刊：
影响因子：
6.9
通讯作者：
Gasperikova, Daniela
中科院分区：
文献类型：
--
作者：
Skopkova, Martina;Penesova, Adela;Gasperikova, Daniela
目的：脂肪组织产生的许多脂肪因子、炎症细胞因子和其他蛋白质已被证明参与肥胖相关胰岛素抵抗的发展。然而，在这些进程中起重要作用的新因素仍在出现。因此，我们筛选了瘦和肥胖受试者皮下脂肪组织（ScAT）活检中120种不同蛋白质的水平。研究方法和程序：所有研究志愿者（12名肥胖，BMI为bb30, 6名瘦，BMI为bb30）
Objective: Many adipokines, inflammatory cytokines, and other proteins produced by adipose tissue have been shown to be involved in the development of obesity-related insulin resistance. Nevertheless, new factors that play an important role in these processes are still emerging. Therefore, we screened the level of 120 different proteins in biopsies of subcutaneous adipose tissue (ScAT) of lean and obese subjects.Research Methods and Procedures: All studied volunteers (12 obese with BMI >30 and 6 lean with BMI