Gender and alcohol dosing: A procedure for producing comparable breath alcohol curves for men and women
Gender and alcohol dosing: A procedure for producing comparable breath alcohol curves for men and women
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DOI：
10.1111/j.1530-0277.1997.tb03860.x
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发表时间：
1997-08-01
影响因子：
3.2
通讯作者：
Cappell, H
中科院分区：
文献类型：
--
作者：
Breslin, FC;Kapur, BM;Cappell, H
酒精管理研究中达到的呼气酒精浓度峰值（brac）的性别差异可能会使研究结果难以解释。本研究评估了CBAC计算机程序作为一种最小化BrAC曲线性别差异的方法。31名女性和27名男性受试者在吃完按体重调整的餐前饮料后，分别饮用了酒精含量为0.04%或0.08%的饮料。女性和男性的平均峰值brac无显著差异。同样，在饮酒后2小时内获得的4个BrAC读数没有显示性别差异，在BrAC达到峰值的时间上观察到剂量与性别的相互作用，只有在高剂量组中，女性达到BrAC峰值的时间比男性快。通过减少BrAC曲线中的性别差异，这种给药程序有助于减少剂量和性别的潜在混淆。
Gender differences in peak breath alcohol concentrations (BrACs) reached in alcohol administration studies can make the interpretation of study findings difficult. This study evaluated the CBAC computer program as a way of mimimizing gender differences in the BrAC curve. After consuming a predrink meal that was adjusted by body mass, 31 female end 27 male subjects consumed an alcoholic beverage targeted for either 0.04% or 0.08%. Mean peak BrACs for women and men were not significantly different. Similarly, the four BrAC readings obtained over the first 2 hr postdrink showed no gender differences, A dose x gender interaction was observed on time to peak BrAC, with women reaching peak BrAC faster than men only in the high dose groups. By decreasing gender differences in BrAC curves, this dosing procedure can aid in reducing the potential confound of dose and gender.