Plasma IL-6 levels correlate with clinical and ultrasound measures of arthritis in patients with systemic lupus erythematosus
Plasma IL-6 levels correlate with clinical and ultrasound measures of arthritis in patients with systemic lupus erythematosus
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DOI：
10.1177/0961203313512882
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发表时间：
2014-01-01
期刊：
影响因子：
2.6
通讯作者：
Rooney, M. R.
中科院分区：
文献类型：
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作者：
Ball, E. M. A.;Gibson, D. S.;Rooney, M. R.
目的探讨特异性细胞因子在狼疮性关节炎(SLE)发病中的作用。方法对50例SLE患者和40例RA患者进行手部超声检查。每个关节的US评分表示为US活动的总评分，(所有关节的能量多普勒(PD)和灰阶滑膜肥大评分之和)和总侵蚀评分。对SLE疾病活动性进行评估(BILAG和Selena-SLEDAI)。结果根据超声检查结果，SLE患者分为侵蚀性关节炎组(n=20)、非侵蚀性关节炎组(n=18)和超声正常组(n=12)。在SLE组中，血浆IL-6水平与CRP呈正相关(p
Objective The objective of this paper is to elucidate the role of specific cytokines in lupus (SLE) arthritis.Methods Fifty SLE and 40 RA patients had an ultrasound (US) scan of their hand as per standardized protocols. US scores were expressed per joint and as a total US activity' score, (sum of power Doppler (PD) and grey-scale synovial hypertrophy scores in all joints) and a total erosion score. SLE disease activity was assessed (BILAG and SELENA-SLEDAI). Plasma levels of IL-6, TNF-alpha and BLyS were measured using sandwich ELISA kits (Quantikine kits, R & D).Results On the basis of the US results SLE patients were divided into three groups: erosive arthritis (n=20), non-erosive arthritis (n=18) and those with a normal US scan (n=12). Across the SLE groups plasma IL-6 levels correlated with CRP (p