Association between levels of high-sensitivity C-reactive protein in plasma and freezing of gait in Parkinson's disease
Association between levels of high-sensitivity C-reactive protein in plasma and freezing of gait in Parkinson's disease
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DOI：
10.1007/s40520-022-02134-8
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发表时间：
2022-04
影响因子：
4
通讯作者：
Jie Liu;Weifang Yin;Chuanbin Zhou;Yan-Ming Zhu;Meijuan Gu;Bin Liu;Hui Ren;Xinglong Yang
中科院分区：
文献类型：
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作者：
Jie Liu;Weifang Yin;Chuanbin Zhou;Yan-Ming Zhu;Meijuan Gu;Bin Liu;Hui Ren;Xinglong Yang
探讨中国帕金森病(PD)患者血浆超敏C反应蛋白水平与步态冻结(FOG)的关系。本研究纳入本中心72例健康受试者、62例有雾的帕金森病患者和83例无雾的帕金森病患者。有雾的患者hs-CRP水平显著高于对照组，而无雾的患者则无显著差异。二分类Logistic回归分析表明，血浆hs-C反应蛋白水平是我们队列中的患者发生雾的独立危险因素(OR 6.371，95%CI 2.589-15.678，p<； 0.001)。事实上，以0.935 mg/L为临界值区分有无雾患者[ROC曲线下面积(AUC) = 0.908，敏感性87.1%，特异性89.2%]。我们的研究表明，血浆中高水平的hs-CRP与帕金森病雾的发生有关。合并后的数据结合之前在西班牙进行的一项研究也表明，血浆hs-CRP水平与帕金森病患者的雾呈正相关。然而，仍需要更多的研究来验证血浆hs-CRP是否为雾的潜在生物标志物。
This study explored the potential relationship between levels of high-sensitivity C-reactive protein (hs-CRP) in plasma and freezing of gait (FOG) in Parkinson's disease (PD) in China. A total of 72 healthy subjects, 62 PD patients with FOG, and 83 PD patients without FOG from our center were enrolled in this prospective study. Patients with FOG showed significantly higher hs-CRP levels than controls, but patients without FOG did not. Binary logistic regression analysis identified levels of hs-CRP in plasma to be an independent risk factor for FOG among the patients in our cohort (OR 6.371, 95% CI 2.589–15.678,p< 0.001). In fact, a cut-off level of 0.935 mg/L distinguished patients with or without FOG [area under the ROC curve (AUC) = 0.908, sensitivity 87.1%, specificity 89.2%]. Our study suggests that high levels of hs-CRP in plasma are associated with the occurrence of FOG in PD. The pooled data combined with a previous study carried out in Spain also indicate a positive association between plasma hs-CRP levels and FOG in PD. However, more research is still needed to verify the plasma hs-CRP as a potential biomarker of FOG.