Ultrafiltration coefficients of glomeruli from human biopsies.
Ultrafiltration coefficients of glomeruli from human biopsies.
复制标题
人体活检肾小球的超滤系数。
DOI：
10.1038/ki.1988.259
复制
发表时间：
1988
影响因子：
19.6
通讯作者：
Savin,VJ
中科院分区：
文献类型：
--
作者：
Richardson,WP;Hassanein,R;Pinnick,RV;Savin,VJ
Ultrafiltration coefficients of glomeruli from human biopsies. Ultrafiltration coefficient (Kf) was measured in vitro using glomeruli isolated from 28 human renal biopsies in order to assess both the relationship between glomerular structure and filtration characteristics and the relationship between Kfand patients' clinical state. The patients, ages 1 to 72 years, had a wide variety of renal diseases and serum creatinines of 1 to 16 mg/dl. Glomeruli were examined by light, immunofluorescence and electron microscopy, and glomerular alterations were measured. Filtration was induced in isolated glomeruli by an oncotic gradient and Kfcalculated. Glomerular diameter (D), averaged for each patient, varied from 131 to 315 µm, and Kfvaried from 5.7 to 51 nl/min · mm Hg. Hydraulic conductivity (Lp) in 15 biopsies averaged 1.45 µ · min-1· mm Hg-1· cm-2. In order to identify the significant predictors of Kfand delineate their relationships, stepwise multiple regression analysis was performed. Kfincreased with increasing glomerular size and with increasing degree of glomerular hypercellularity. D, in turn, increased with body surface area, urinary protein, and degree of capillary damage, and decreased with percent senescent glomeruli and degree of epithelial foot process broadening. Kfdid not significantly correlate with clinical measures of renal function.
