Survival from salivary glands adenoid cystic carcinoma in European populations
Survival from salivary glands adenoid cystic carcinoma in European populations
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DOI：
10.1016/j.oraloncology.2008.10.010
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发表时间：
2009-08-01
期刊：
影响因子：
4.8
通讯作者：
Gatta, Gemma
中科院分区：
文献类型：
--
作者：
Ciccolallo, Laura;Licitra, Lisa;Gatta, Gemma
摘要涎腺腺样囊性癌是一种罕见的肿瘤。EUROCARE的数据提供了一个很好的机会来研究这种罕见癌症在大人群中的生存率。本文分析了1983 ~ 1994年间2611例15 ~ 99岁原发性涎腺腺样囊性癌的临床资料。来自17个参与EUROCARE的国家的32个基于人群的癌症登记处提供了数据。根据性别、年龄、诊断期、地区、部位和分期以及校正的死亡相对超额风险（RER）估计相对生存率。诊断后1年、5年和10年的生存率分别为94%、78%和65%。最年轻年龄组（15-54岁）和来自北方欧洲（69%）的患者的10年生存率最高（69%）。英国的比例（65%）高于西欧（62%）和东欧（56%）。鼻腔、咽部和喉支气管腺癌的预后较口腔腺癌差，分别为2.6、3.5和3.9。诊断时的分期对RERs有很强的影响，随着时间的推移，5年生存率也有所下降（1983-1985年为80%，1992-1994年为76%）。本研究的结果，从临床研究，证实了原发部位和阶段在诊断生存的重要影响。此外，我们可以证明ACC的生存率并没有随着时间的推移而改善，并且来自东方国家的病例预后明显更差。应鼓励改进疾病早期检测和国际合作研究。(C)2008爱思唯尔有限公司保留所有权利。
Adenoid cystic carcinoma (ACC) of salivary gland origin is rare. The EUROCARE data provide a good opportunity to study the survival of this uncommon cancer in a large population. A total of 2611 cases, aged 15 to 99 years, diagnosed between 1983 and 1994 with primary salivary gland ACC were analyzed. Thirty-two population based cancer registries from seventeen countries participating in EUROCARE contributed the data. Relative survival by sex, age, period of diagnosis, region, site and stage, and the adjusted relative excess risk (RER) of death were estimated. Survival since diagnosis was 94%, 78% and 65% at 1, 5 and ten years, respectively. Ten-year survival was best (69%) in patients of the youngest age group (15-54 years) and from Northern Europe (69%). In the UK was higher (65%) than in Western (62%) and Eastern (56%) Europe. ACCs in nasal cavity (RER 2.6), pharynx (RER 3.5) and larynx and bronchus (RER 3.9) had a worse prognosis compared to those of oral cavity. A strong effect of stage at diagnosis on RERs and some worsening of survival at five years over time (80% in 1983-1985, 76% in 1992-1994) were also evident. The findings of the present study, as those from clinical studies, confirm the important impact of primary site and stage at diagnosis on survival. Furthermore, we could demonstrate that survival for ACC did not improve over time and that cases from Eastern countries had a significant worse prognosis. Improvements in the disease detection in its early stage and international collaborative research should be encouraged. (C) 2008 Elsevier Ltd. All rights reserved.