Intra-individual and inter-individual variations in iodine intake and excretion in adult women: implications for sampling
Intra-individual and inter-individual variations in iodine intake and excretion in adult women: implications for sampling
复制标题
成年女性碘摄入和排泄的个体内和个体间差异：对抽样的影响
DOI：
10.1017/s0007114519003015
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发表时间：
2020-05-14
影响因子：
3.6
通讯作者：
Shen, Jun
中科院分区：
文献类型：
--
作者：
Chen, Wen;Gao, Shu;Shen, Jun
摘要碘的摄入和排泄变化很大，然而，这些变化仍然是一个很大的几何不确定性的来源。本研究旨在分析碘摄入量和排泄量的变化，并为个人或群体研究中的抽样提供启示。在为期4周的实验中，24名健康女性志愿者被招募为12天的采样期。重复部分技术被用来测量碘摄入量，而24小时尿收集估计碘排泄。碘摄入量、24小时UIE（24小时尿碘排泄）和24小时UIC（24小时尿碘浓度）的平均个体内变异分别为63%、48%和55%，而这些参数的个体间变异分别为14%、24%和32%。对于95%的置信度，应从个体中采集约500份饮食样本或24小时尿液样本，以在± 5%的精度范围内估计其碘摄入量或碘状态。在人群中获得±5%的精确度范围需要25份饮食样本或150份24小时尿液样本。碘摄入和排泄的个体内变异高于个体间变异，这表明在对个体参与者的研究中需要更多样本。
Abstract Iodine intake and excretion vary widely; however, these variations remain a large source of geometric uncertainty. The present study aims to analyse variations in iodine intake and excretion and provide implications for sampling in studies of individuals or populations. Twenty-four healthy women volunteers were recruited for a 12-d sampling period during the 4-week experiment. The duplicate-portion technique was used to measure iodine intake, while 24-h urine was collected to estimate iodine excretion. The mean intra-individual variations in iodine intake, 24-h UIE (24-h urinary iodine excretion) and 24-h UIC (24-h urinary iodine concentration) were 63, 48 and 55 %, respectively, while the inter-individual variations for these parameters were 14, 24 and 32 %, respectively. For 95 % confidence, approximately 500 diet samples or 24-h urine samples should be taken from an individual to estimate their iodine intake or iodine status at a precision range of ±5%. Obtaining a precision range of ±5% in a population would require twenty-five diet samples or 150 24-h urine samples. The intra-individual variations in iodine intake and excretion were higher than the inter-individual variations, which indicates the need for more samples in a study on individual participants.