Mechanism of H₂ histamine receptor dependent modulation of body temperature and neuronal activity in the medial preoptic nucleus.
Mechanism of H₂ histamine receptor dependent modulation of body temperature and neuronal activity in the medial preoptic nucleus.
复制标题
H组胺受体依赖性调节体温和内侧视前核神经元活动的机制。
DOI：
10.1016/j.neuropharm.2012.02.006
复制
发表时间：
2012
影响因子：
4.7
通讯作者：
Sethi,Jasmine
中科院分区：
文献类型：
--
作者：
Tabarean,IustinV;Sanchez-Alavez,Manuel;Sethi,Jasmine
Histamine is involved in the central control of arousal, circadian rhythms and metabolism. The preoptic area, a region that contains thermoregulatory neurons is the main locus of histamine modulation of body temperature. Here we report that in mice, histamine activates H2subtype receptors in the medial preoptic nucleus (MPON) and induces hyperthermia. We also found that a population of glutamatergic MPON neurons express H2receptors and are excited by histamine or H2specific agonists. The agonists decreased the input resistance of the neuron and increased the depolarizing “sag” observed during hyperpolarizing current injections. Furthermore, at −60mV holding potential, activation of H2receptors induced an inward current that was blocked by ZD7288, a specific blocker of the hyperpolarization activated cationic current (Ih). Indeed, activation of H2receptors resulted in increased Ihamplitude in response to hyperpolarizing voltage steps and a depolarizing shift in its voltage-dependent activation. The neurons excited by H2specific agonism expressed the HCN1 and HCN2 channel subunits. Our data indicate that at the level of the MPON histamine influences thermoregulation by increasing the firing rate of glutamatergic neurons that express H2receptors.
