Perceptual knowledge retrieval activates sensory brain regions
Perceptual knowledge retrieval activates sensory brain regions
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DOI：
10.1523/jneurosci.5389-05.2006
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发表时间：
2006-05-03
影响因子：
5.3
通讯作者：
Schneider, W
中科院分区：
文献类型：
--
作者：
Goldberg, RF;Perfetti, CA;Schneider, W
虽然知识是我们对世界的经验的索引，但这种关系的神经基础仍有待确定。以前的神经影像学研究，特别是涉及知识偏向于视觉和功能信息，表明语义表征依赖于特定的模式的大脑机制。然而，目前还不清楚是否感觉皮层区域，一般来说，支持检索的知觉知识。使用神经影像学方法，我们表明，索引触觉，味觉，听觉和视觉知识的语义决定，具体激活与编码这些感官体验相关的大脑区域。触觉知识的检索与体感，运动和运动前皮质区域的激活增加特别相关。与此相反，涉及口味知识的决定增加了先前参与处理可食用物品之间的语义比较的眶额区的激活。参考视觉和听觉经验的感知知识检索与参与各自感觉处理的不同颞脑区域的活动增加有关。这些结果表明，知觉知识的检索依赖于大脑区域用于调解感官经验与参考对象。
Although knowledge indexes our experiences of the world, the neural basis of this relationship remains to be determined. Previous neuroimaging research, especially involving knowledge biased to visual and functional information, suggests that semantic representations depend on modality-specific brain mechanisms. However, it is unclear whether sensory cortical regions, in general, support retrieval of perceptual knowledge. Using neuroimaging methods, we show that semantic decisions that index tactile, gustatory, auditory, and visual knowledge specifically activate brain regions associated with encoding these sensory experiences. Retrieval of tactile knowledge was specifically associated with increased activation in somatosensory, motor, and premotor cortical regions. In contrast, decisions involving flavor knowledge increased activation in an orbitofrontal region previously implicated in processing semantic comparisons among edible items. Perceptual knowledge retrieval that references visual and auditory experiences was associated with increased activity in distinct temporal brain regions involved in the respective sensory processing. These results indicate that retrieval of perceptual knowledge relies on brain regions used to mediate sensory experiences with the referenced objects.