Psychophysiological Mechanisms of Interindividual Differences in Goal Activation Modes During Action Cascading
Psychophysiological Mechanisms of Interindividual Differences in Goal Activation Modes During Action Cascading
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DOI：
10.1093/cercor/bht066
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发表时间：
2014-08-01
期刊：
影响因子：
3.7
通讯作者：
Beste, Christian
中科院分区：
文献类型：
--
作者：
Mueckschel, Moritz;Stock, Ann-Kathrin;Beste, Christian
我们日常生活的特点是需要级联多个响应选项，以避免有限的响应选择资源过度使用。虽然动作级联中的响应选择和目标激活可能是由从串行处理到并行处理的不同过程驱动的，但人们对这些响应选择模式中可能存在个体间差异的潜在神经机制知之甚少。为了研究这些机制，我们使用停止变化范例来记录健康受试者的事件相关电位和标准化低分辨率脑电磁断层扫描源定位。系统地改变刺激开始的异步性（“停止”和“改变”信号的时间间隔），我们应用数学约束在动作级联过程中以更并行或更串行的目标激活器对受试者进行分类。在此基础上，电生理学数据表明，连接刺激处理和反应执行的过程（而不是注意力过程）是动作级联过程中串行或并行反应选择模式的个体间差异的基础。在系统层面上，这些过程是通过分布式额顶叶网络介导的，包括前扣带皮层（布罗德曼区 32，BA32）和颞顶叶交界处（BA40）。激活的任务目标和电生理过程的个体重叠程度之间存在线性关系。
Our daily life is characterized by multiple response options that need to be cascaded in order to avoid overstrain of restricted response selection resources. While response selection and goal activation in action cascading are likely driven by a process varying from serial to parallel processing, little is known about the underlying neural mechanisms that may underlie interindividual differences in these modes of response selection. To investigate these mechanisms, we used a stop-change paradigm for the recording of event-related potentials and standardized low resolution brain electromagnetic tomography source localizations in healthy subjects. Systematically varying the stimulus onset asynchrony (the temporal spacing of "stop" and "change" signals), we applied mathematical constraints to classify subjects in more parallel or more serial goal activators during action cascading. On that basis, the electrophysiological data show that processes linking stimulus processing and response execution, but not attentional processes, underlie interindividual differences in either serial or parallel response selection modes during action cascading. On a systems level, these processes were mediated via a distributed fronto-parietal network, including the anterior cingulate cortex (Brodman area 32, BA32) and the temporo-parietal junction (BA40). There was a linear relation between the individual degree of overlap in activated task goals and electrophysiological processes.