PDZ adaptors: their regulation of epithelial transporters and involvement in human diseases.
PDZ adaptors: their regulation of epithelial transporters and involvement in human diseases.
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PDZ 适配器：它们对上皮转运蛋白的调节并参与人类疾病。
DOI：
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Y. Kato
中科院分区：
文献类型：
--
作者：
T. Sugiura;T. Shimizu;Ai Kijima;Sosuke Minakata;Y. Kato
体内的稳态至少部分是通过控制膜通透性的机制来维持的，从而控制上皮细胞中必需物质（如营养物质）的摄取和不需要物质（如异种生物和代谢物）的排出。各种转运蛋白在这种双向转运中起着重要作用，但对它们如何在质膜上组织知之甚少。蛋白-蛋白相互作用可能起关键作用：上皮细胞中的几种转运蛋白与所谓的衔接蛋白相互作用，衔接蛋白是膜锚定的，与转运蛋白和其他膜蛋白相互作用。虽然大多数转运体-接头相互作用的证据都是在体外获得的，但最近的研究表明，接头介导的转运体调节确实发生在体内，并且可能与人类疾病有关。因此，蛋白质-蛋白质相互作用不仅与大分子复合物的形成有关，而且还参与各种细胞事件，并可能通过在质膜上形成转运蛋白网络为转运蛋白提供额外的功能。外源性转运体与PSD95/Dlg/ZO1 （PDZ）接头之间的相互作用此前由Kato和Tsuji（2006）进行了综述。[J]；本文主要综述了PDZ接头作为转运体网络的调节因子及其在人类疾病中的潜在作用的最新发现。
Homeostasis in the body is at least partially maintained by mechanisms that control membrane permeability, and thereby serve to control the uptake of essential substances (e.g., nutrients) and the efflux of unwanted substances (e.g., xenobiotics and metabolites) in epithelial cells. Various transporters play fundamental roles in such bidirectional transport, but little is known about how they are organized on plasma membranes. Protein-protein interactions may play a key role: several transporters in epithelial cells interact with the so-called adaptor proteins, which are membrane anchored and interact with both transporters and other membranous proteins. Although most of the evidences for transporter-adaptor interaction has been obtained in vitro, recent studies suggest that adaptor-mediated transporter regulation does occur in vivo and could be relevant to human diseases. Thus, protein-protein interaction is not only associated with the formation of macromolecular complexes but is also involved in various cellular events, and may provide transporters with additional functionality by forming transporter networks on plasma membranes. Interactions between xenobiotic transporters and PSD95/Dlg/ZO1 (PDZ) adaptors were previously reviewed by Kato and Tsuji (2006. Eur J Pharm Sci 27:487-500); the present review focuses on the latest findings about PDZ adaptors as regulators of transporter networks and their potential role in human diseases.
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影响因子：
9.7
作者：
Li, Chunying;Schuetz, John D.;Naren, Anjaparavanda P.
通讯作者：
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DOI：
10.1152/ajprenal.90657.2008
发表时间：
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期刊：
American journal of physiology. Renal physiology
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DOI：
10.1016/j.bbadis.2008.02.004
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2008-05-01
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DOI：
10.1073/pnas.0506578102
发表时间：
2005
影响因子：
11.1
作者：
Thomson,RBrent;Wang,Tong;Thomson,BenjaminR;Tarrats,Luis;Girardi,Adriana;Mentone,SueAnn;Soleimani,Manoocher;Kocher,Olivier;Aronson,PeterS
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影响因子：
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作者：
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