Sex chromosome inactivation in germ cells: emerging roles of DNA damage response pathways.
Sex chromosome inactivation in germ cells: emerging roles of DNA damage response pathways.
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DOI：
10.1007/s00018-012-0941-5
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发表时间：
2012-08
影响因子：
8
通讯作者：
Namekawa, Satoshi H.
中科院分区：
文献类型：
--
作者：
Ichijima, Yosuke;Sin, Ho-Su;Namekawa, Satoshi H.
Sex chromosome inactivation in male germ cells is a paradigm of epigenetic programming during sexual reproduction. Recent progress has revealed the underlying mechanisms of sex chromosome inactivation in male meiosis. The trigger of chromosome-wide silencing is activation of the DNA damage response (DDR) pathway, which is centered on the mediator of DNA damage checkpoint 1 (MDC1), a binding partner of phosphorylated histone H2AX (γH2AX). This DDR pathway shares features with the somatic DDR pathway recognizing DNA replication stress in the S phase. Additionally, it is likely to be distinct from the DDR pathway that recognizes meiosis-specific double-strand breaks. This review article extensively discusses the underlying mechanism of sex chromosome inactivation.
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影响因子：
4.5
作者：
Anguera MC;Ma W;Clift D;Namekawa S;Kelleher RJ 3rd;Lee JT
通讯作者：
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Collis, Spencer J.;Ciccia, Alberto;Boulton, Simon J.
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DOI：
10.1073/pnas.0910267107
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