An Inexpensive, Portable Device for Point-of-Need Generation of Silver-Nanoparticle Doped Cellulose Acetate Nanofibers for Advanced Wound Dressing
An Inexpensive, Portable Device for Point-of-Need Generation of Silver-Nanoparticle Doped Cellulose Acetate Nanofibers for Advanced Wound Dressing
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DOI：
10.1002/mame.201700586
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发表时间：
2018-05-01
影响因子：
3.9
通讯作者：
Edirisinghe, Mohan
中科院分区：
文献类型：
--
作者：
Brako, Francis;Luo, Chaojie;Edirisinghe, Mohan
这篇简短的通讯描述了一种新型小型静电纺丝器的设计和组装，以在需要药物输送和伤口敷料应用的部位生产纳米纤维。该便携式设备将消除由于载药纳米纤维的脆弱性而引起的存储和运输问题，从而在使用现场保持产品的完整性。此外，与那些定制且更昂贵的现有设备相比，该设置具有更小的尺寸、更便宜的价格以及易于获得现成的组件，这使得该领域的其他用户渴望且易于使用。作为伤口护理的概念验证，该设备成功用于静电纺丝由纯醋酸纤维素 (CA) 和分别掺杂 0.75 和 1.5 wt% 银纳米粒子的 CA 组成的三种纳米纤维。由于静电纺丝的普及以及由于从产品生产到需要时减少了敷料和伤口的操作而有可能最大限度地减少伤口感染，因此小型化装置非常有用。目前正在进一步开发便携式设备，并将其产品性能与传统伤口敷料材料进行比较，以进行临床转化。
This short communication describes the design and assembly of a new, miniaturized electrospinner to produce nanofibers at the site of need for drug delivery and wound dressing applications. The portable apparatus would eliminate the storage and transportation concerns with regards to the delicate nature of drug-loaded nanofibers, thereby preserving product integrity at the site of use. Furthermore, the setup features a smaller size, a cheaper price, and components that are readily obtainable off-the-shelf, compared to those of available devices that are custom-built and more expensive, making it desirable and accessible for other users in the field. As a proof-of-concept for wound care, the device is successfully used to electrospin three types of nanofibers comprised of pure cellulose acetate (CA), and CA respectively doped with 0.75 and 1.5 wt% silver nanoparticles. The miniaturized device is useful on account of the popularity of electrospinning as well as the potential to minimize wound infection due to the reduced manipulation of both the dressing and the wound from product generation to the point of need. Work is in progress to further develop the portable device and compare its product performance with traditional wound dressing materials for clinical translation.