Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans
Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans
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DOI：
10.1111/j.1474-9726.2006.00266.x
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发表时间：
2007-02-01
期刊：
影响因子：
7.8
通讯作者：
Kapahi, Pankaj
中科院分区：
文献类型：
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作者：
Pan, Kally Z.;Palter, Julia E.;Kapahi, Pankaj
蛋白质合成是一个受调控的细胞过程，将环境中的营养物质与生物体的生长和发育联系起来。在这里，我们研究了调节mRNA翻译的基因在决定生长，繁殖，抗应激和寿命中的作用。蛋白质合成的翻译控制的调节剂，如帽结合复合物和S6激酶在生长过程中发挥重要作用。我们观察到，抑制翻译起始复合物中的各种基因，包括ifg-1，eIF 4G的蠕虫同源物，这是帽结合复合物中的支架蛋白;和rsks-1，S6激酶的蠕虫同源物，导致秀丽隐杆线虫的寿命延长。抑制ifg-1或rsks-1也会减缓发育，降低繁殖力，并增强对饥饿的抵抗力。还观察到dauer中ifg-1表达的减少，表明在dauer状态期间蛋白质翻译的抑制。因此，mRNA翻译对C.优雅的
Protein synthesis is a regulated cellular process that links nutrients in the environment to organismal growth and development. Here we examine the role of genes that regulate mRNA translation in determining growth, reproduction, stress resistance and lifespan. Translational control of protein synthesis by regulators such as the cap-binding complex and S6 kinase play an important role during growth. We observe that inhibition of various genes in the translation initiation complex including ifg-1, the worm homologue of eIF4G, which is a scaffold protein in the cap-binding complex; and rsks-1, the worm homologue of S6 kinase, results in lifespan extension in Caenorhabditis elegans. Inhibition of ifg-1 or rsks-1 also slows development, reduces fecundity and increases resistance to starvation. A reduction in ifg-1 expression in dauers was also observed, suggesting an inhibition of protein translation during the dauer state. Thus, mRNA translation exerts pleiotropic effects on growth, reproduction, stress resistance and lifespan in C. elegans.